An efficient and eco-friendly synthesis and evaluation of antibactrial activity of pyrano[2,3-c]pyrazole derivatives

被引：39

作者：

Mamaghani, Manouchehr ^{[1
]}

Nia, Roghayeh Hossein ^{[1
]}

Shirini, Farhad ^{[1
]}

Tabatabaeian, Khalil ^{[1
]}

Rassa, Mehdi ^{[2
]}

机构：

[1] Univ Guilan, Dept Chem, Fac Sci, Rasht, Iran

[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 05期

关键词：

Hydrazine hydrate; Pyrano[2,3-c]pyrazole; Solvent-free; Ionic liquid; Antibacterial; Spiro; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; IONIC LIQUID; CATALYST; IDENTIFICATION; MICROWAVE; FACILE; WATER;

D O I：

10.1007/s00044-014-1271-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid, straightforward, and highly efficient one-pot synthesis of pyrano[2,3-c]pyrazole derivatives and spiro-conjugated pyrano[2,3-c]pyrazole has been developed based on newly introduced and environmentally benign Bronsted-acidic ionic liquid catalyst [DMBSI]HSO4 via one-pot four-component reaction under solvent-free conditions. The synthesized compounds were screened for their antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria.

引用

收藏

页码：1916 / 1926

页数：11

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