The role of hypoxia-inducible factor-1 alpha in multidrug-resistant breast cancer

被引：49

作者：

Yong, Liyun ^{[1
]}

Tang, Shasha ^{[1
]}

Yu, Haixin ^{[2
]}

Zhang, Hongyi ^{[1
]}

Zhang, Yi ^{[1
]}

Wan, Yuan ^{[3
]}

Cai, Fengfeng ^{[1
]}

机构：

[1] Tongji Univ, Yangpu Hosp, Sch Med, Dept Breast Surg, Shanghai, Peoples R China

[2] Tongji Univ, Yangpu Hosp, Sch Med, Dept Orthoped Surg, Shanghai, Peoples R China

[3] Binghamton Univ, Dept Biomed Engn, Pq Lab BiomeDx Rx, SUNY, Binghamton, NY 13902 USA

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

上海市自然科学基金;

关键词：

breast cancer; drug; resistance; inhibition; hypoxia inducible factor-1 Alpha (HIF-1 alpha); targeted drugs; MEDIATED DRUG-RESISTANCE; CELL-DEATH; TRANSCRIPTIONAL ACTIVITY; INDUCED CHEMORESISTANCE; TUMOR ANGIOGENESIS; ANTITUMOR-ACTIVITY; FACTOR; 1-ALPHA; HIF-1-ALPHA; HIF; OXYGEN;

D O I：

10.3389/fonc.2022.964934

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common cancer in women worldwide with increasing incidence. Significant therapeutics advances in the field of breast cancer have resulted in a growing number of treatment options, whereas de novo or acquired resistance is still a persistent clinical challenge. Drug resistance involves a variety of mechanisms, and hypoxia is one of the many causes. Hypoxia-inducible Factor-1 Alpha (HIF-1 alpha) is a key transcription factor which can regulate the response of cells to hypoxia. HIF-1 alpha can trigger anaerobic glycolysis of tumor cells, induce angiogenesis, promote the proliferation, invasion, and migration of tumor cells, and lead to multidrug resistance. This review mainly discusses the role of HIF-1 alpha in the drug-resistant breast cancer and highlighted the potential of HIF-1 alpha -targeted therapy.

引用

页数：13

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