Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus

被引：194

作者：

Yang, Li-Min ^{[1
]}

Hu, Bing ^{[1
]}

Xia, Ying-Hong ^{[1
]}

Zhang, Bei-Lin ^{[1
]}

Zhao, Hua ^{[1
]}

机构：

[1] Jilin Univ, Sch Basic Med Sci, Dept Physiol, Changchun 130021, Peoples R China

来源：

BEHAVIOURAL BRAIN RESEARCH | 2008年 / 188卷 / 01期

基金：

中国国家自然科学基金;

关键词：

lateral habenula; depression; forced-swimmin test; microdialysis; serotonin; dorsal raphe nucleus; rats;

D O I：

10.1016/j.bbr.2007.10.022

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The dorsal raphe nucleus (DRN)-serotonin (5-HT) system plays a key role in stress-related psychiatric disorders such as anxiety and depression. The habenular nucleus (Hb) is closely connected with the DRN both morphologically and functionally. Here, we used two types of depressive animal models by exposing rats to chronic mild stress (CMS) and by chronically administering the tricyclic antidepressant clomipramine (CLI) in the rat during the neonatal state of life to produce adult depressed rats. We investigated the effects of lateral habenular nucleus (LHb) lesions on the behavioral response and on the level of 5-HT in DRN in the depressed rats. Forced-swimming test (FST) showed that the immobility time decreased, and the climbing time increased after lesioning LHb of depressed rats. Microdialysis results indicated that the 5-HT level in DRN in depressed rats was lower than that of the control group. Lesion of the LHb was followed by an increased 5-HT turnover in the DRN. Our results suggested that the lesion of the LHb could improve the behavioral response of the depressed rats and the 5-HT level of the DRN increased by LHb lesions could be involved in the effects. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：84 / 90

页数：7

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