Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassemia major: the DEEP-3 multi-center observational safety study

被引：14
作者：
Botzenhardt, Sebastian [1 ]
Felisi, Mariagrazia [2 ]
Bonifazi, Donato [2 ]
Del Vecchio, Giovanni C. [3 ]
Putti, Maria C. [4 ]
Kattamis, Antonis [5 ]
Ceci, Adriana [2 ,6 ]
Wong, Ian C. K. [7 ,8 ]
Neubert, Antje [1 ]
机构：
[1] Friedrich Alexander Univ Erlangen Nurnberg FAU, Fac Med, Dept Paediat & Adolescent Med, Erlangen, Germany
[2] Consorzio Valutazioni Biol & Farmacol, Pavia, Italy
[3] Policlin Bari, Azienda Osped Univ Consorziale, Bari, Italy
[4] Azienda Osped Padova, Clin Oncoemat Pediat, Padua, Italy
[5] Univ Athens, Dept Pediat 1, Athens, Greece
[6] Gianni Benzi Pharmacol Res Fdn, Bari, Italy
[7] UCL, Sch Pharm, Res Dept Practice & Policy, Ctr Med Optimisat Res & Educ, London, England
[8] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Ctr Safe Medicat Practice & Res, Hong Kong, Hong Kong, Peoples R China
来源：
HAEMATOLOGICA | 2018年 / 103卷 / 01期
关键词：
ORAL IRON CHELATOR; TRANSFUSION-DEPENDENT THALASSEMIA; THERAPY; EFFICACY; OVERLOAD; TRIAL; AGRANULOCYTOSIS; DEFEROXAMINE;
D O I：
10.3324/haematol.2017.176065
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 15 条
[1]   LONG-TERM ASSESSMENT OF EFFICACY AND SAFETY OF L1, AN ORAL IRON CHELATOR, IN TRANSFUSION DEPENDENT THALASSEMIA - INDIAN TRIAL [J].
AGARWAL, MB ;
GUPTE, SS ;
VISWANATHAN, C ;
VASANDANI, D ;
RAMANATHAN, J ;
DESAI, N ;
PUNIYANI, RR ;
CHHABLANI, AT .
BRITISH JOURNAL OF HAEMATOLOGY, 1992, 82 (02) :460-466
[2]   Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major [J].
Borgna-Pignatti, C ;
Cappellini, MD ;
De Stefano, P ;
Del Vecchio, GC ;
Forni, GL ;
Gamberini, MR ;
Ghilardi, R ;
Piga, A ;
Romeo, MA ;
Zhao, HQ ;
Cnaan, A .
BLOOD, 2006, 107 (09) :3733-3737
[3]   Safety profiles of iron chelators in young patients with haemoglobinopathies [J].
Botzenhardt, Sebastian ;
Li, Niya ;
Chan, Esther W. ;
Sing, Chor Wing ;
Wong, Ian C. K. ;
Neubert, Antje .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2017, 98 (03) :198-217
[4]   Safety Profile of Oral Iron Chelator Deferiprone in Chinese Children with Transfusion-Dependent Thalassaemia [J].
Botzenhardt, Sebastian ;
Sing, Chor W. ;
Wong, Ian C. K. ;
Chan, Godfrey Chi-Fung ;
Wong, Lisa Y. L. ;
Felisi, Mariagrazia ;
Rascher, Wolfgang ;
Ceci, Adriana ;
Neubert, Antje .
CURRENT DRUG SAFETY, 2016, 11 (02) :137-144
[5]   The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients [J].
Ceci, A ;
Baiardi, P ;
Felisi, M ;
Cappellini, MD ;
Carnelli, V ;
De Sanctis, V ;
Galanello, R ;
Maggio, A ;
Masera, G ;
Piga, A ;
Schettini, F ;
Stefàno, I ;
Tricta, F .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (01) :330-336
[6]   Deferiprone, Efficacy and Safety [J].
Choudhry V.P. ;
Pati H.P. ;
Saxena A. ;
Malaviya A.N. .
The Indian Journal of Pediatrics, 2004, 71 (3) :213-216
[7]   Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone [J].
Cohen, AR ;
Galanello, R ;
Piga, A ;
De Sanctis, V ;
Tricta, F .
BLOOD, 2003, 102 (05) :1583-1587
[8]   The Safety, Tolerability, and Efficacy of a Liquid Formulation of Deferiprone in Young Children With Transfusional Iron Overload [J].
El Alfy, Moshen ;
Sari, Teny Tjitra ;
Lee, Chan Lee ;
Tricta, Fernando ;
El-Beshlawy, Amal .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2010, 32 (08) :601-605
[9]   Continuation of deferiprone therapy in patients with mild neutropenia may not lead to a more severe drop in neutrophil count [J].
El-Beshlawy, Amal M. ;
El-Alfy, Mohsen S. ;
Sari, Teny T. ;
Chan, Lee L. ;
Tricta, Fernando .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 92 (04) :337-340
[10]   Deviating From Safety Guidelines During Deferiprone Therapy in Clinical Practice May Not be Associated With Higher Risk of Agranulocytosis [J].
Elalfy, Mohssen ;
Wali, Yasser A. ;
Qari, Mohamad ;
Al Damanhouri, Ghazi ;
Al-Tonbary, Youssef ;
Yazman, Dilek ;
Al Hawsawi, Zakaria ;
Karakas, Zeynep ;
Kilinc, Yurdanur ;
Yesilipek, M. Akif ;
Badr, Mohamed ;
Elsafy, Usama ;
Salama, Mostafa ;
Rahman, Yousryeia Abdel ;
Shebl, Shebl ;
Stilman, Anne ;
Temin, Noemi Toiber ;
Tricta, Fernando .
PEDIATRIC BLOOD & CANCER, 2014, 61 (05) :879-884
12