Acyclic amino acid-catalyzed direct asymmetric aldol reactions:: alanine, the simplest stereoselective organocatalyst

被引：236

作者：

Córdova, A ^{[1
]}

Zou, WB ^{[1
]}

Ibrahem, I ^{[1
]}

Reyes, E ^{[1
]}

Engqvist, M ^{[1
]}

Liao, WW ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 28期

关键词：

D O I：

10.1039/b507968n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole 3 and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.

引用

收藏

页码：3586 / 3588

页数：3

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