In vitro activity of 1H-phenalen-1-one derivatives against Acanthamoeba castellanii Neff and their mechanisms of cell death

被引：7
|
作者：
Lopez-Arencibia, Atteneri [1 ]
Reyes-Batlle, Maria [1 ]
Blanco Freijo, Monica [2 ]
McNaughton-Smith, Grant [3 ]
Martin-Rodriguez, Patricia [3 ,4 ]
Fernandez-Perez, Leandro [3 ,4 ]
Sifaoui, Ines [1 ]
Wagner, Carolina [1 ,5 ]
Garcia-Mendez, Ana B. [1 ]
Rizo Liendo, Aitor [1 ]
Bethencourt-Estrella, Carlos J. [1 ]
Abad-Grillo, Teresa [2 ]
Pinero, Jose E. [1 ]
Lorenzo-Morales, Jacob [1 ]
机构：
[1] Univ La Laguna, Univ Inst Trop Dis & Publ Hlth Canary Islands, Avda Astrofis Fco Sanchez S-N, Tenerife 38203, Canary Islands, Spain
[2] Univ La Laguna, Dept Quim Organ, Inst Univ Bioorgan Antonio Gonzalez, Avda Fco Sanchez 2, E-38206 Tenerife, Spain
[3] PCTT, Ctr Atlantico Medicamento SA CEAMED SA, Tenerife, Spain
[4] Univ Las Palmas GC, Dept Clin Sci, Mol & Translat Endocrinol Grp, Canc Res Inst Canary Islands ICIC, Las Palmas Gran Canaria, Spain
[5] Univ Cent Venezuela, Fac Med, Escuela Bioanal, Catedra Parasitol, Caracas, Venezuela
来源：
EXPERIMENTAL PARASITOLOGY | 2017年 / 183卷
关键词：
GENE SEQUENCE TYPE; KERATITIS; IDENTIFICATION; APOPTOSIS; GENOTYPE; T4; PATHOGENICITY; PHYTOALEXINS; RESISTANCE; STRAINS;
D O I：
10.1016/j.exppara.2017.09.012
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-threatening ulceration of the cornea known as Acanthamoeba keratitis (AK) and, more rarely, an infection of the central nervous system called "granulomatous amoebic encephalitis" (GAE). The symptoms of AK are non-specific, and so it can be misdiagnosed as a viral, bacterial, or fungal keratitis. Furthermore, current therapeutic measures against AK are arduous, and show limited efficacy against the cyst stage of Accaithamoeba. 1H-Phenalen-1-one (PH) containing compounds have been isolated from plants and fungi, where they play a crucial role in the defense mechanism of plants. Natural as well as synthetic PHs exhibit a diverse range of biological activities against fungi, protozoan parasites or human cancer cells. New synthetic PHs have been tested in this study and they show a potential activity against this protozoa. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：218 / 223
页数：6
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