A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma

被引：7
作者：
Han, Naihan [1 ,2 ]
Wang, Wenshuang [1 ,2 ]
Lu, Danrong [1 ,2 ]
Wang, Han [1 ,2 ]
Ma, Xinying [3 ]
Fan, Xiaopeng [4 ]
Li, Fuchuan [1 ,2 ]
机构：
[1] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Shandong, Peoples R China
[2] Shandong Univ, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan 250100, Shandong, Peoples R China
[3] Heze Univ, Dept Chem & Chem Engn, Heze 274015, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Hepatol, Jinan 250100, Shandong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 90期
基金：
中国国家自然科学基金;
关键词：
RESONANCE ENERGY-TRANSFER; ALPHA-FETOPROTEIN; GRAPHENE OXIDE; PROTEOGLYCANS; DROSOPHILA; DIAGNOSIS; PROTEIN; AFP; IMMUNOASSAY; EXPRESSION;
D O I：
10.1039/c7cc06305a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on multiple interactions and fluorescence quenching, we report a novel homogeneous detection method for Glypican-3 which shows a series of significant advantages, including low cost, ease of preparation, rapid response, and high sensitivity and has great potential in the clinical diagnosis of hepatocellular carcinoma and proteoglycan detection.
引用
收藏
页码：12209 / 12212
页数：4
相关论文
共 43 条
[1]   Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy [J].
Anatelli, Florencia ;
Chuang, Shang-Tian ;
Yang, Ximing J. ;
Wang, Hanlin L. .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 130 (02) :219-223
[2]   Management of hepatoceullular carcinoma [J].
Bruix, J ;
Sherman, M .
HEPATOLOGY, 2005, 42 (05) :1208-1236
[3]   Glypican-3: A novel serum and histochemical marker for hepatocellular carcinoma [J].
Capurro, M ;
Wanless, IR ;
Sherman, M ;
Deboer, G ;
Shi, W ;
Miyoshi, E ;
Filmus, J .
GASTROENTEROLOGY, 2003, 125 (01) :89-97
[4]   Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling [J].
Capurro, MI ;
Xiang, YY ;
Lobe, C ;
Filmus, J .
CANCER RESEARCH, 2005, 65 (14) :6245-6254
[5]   Graphene Fluorescence Resonance Energy Transfer Aptasensor for the Thrombin Detection [J].
Chang, Haixin ;
Tang, Longhua ;
Wang, Ying ;
Jiang, Jianhui ;
Li, Jinghong .
ANALYTICAL CHEMISTRY, 2010, 82 (06) :2341-2346
[6]   Sensitive sandwich electrochemical immunosensor for on prussian blue modified hydroxyapatite [J].
Dai, Yuxue ;
Cai, Yanyan ;
Zhao, Yanfang ;
Wu, Dan ;
Liu, Bao ;
Li, Ru ;
Yang, Minghui ;
Wei, Qin ;
Du, Bin ;
Li, He .
BIOSENSORS & BIOELECTRONICS, 2011, 28 (01) :112-116
[7]   The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila [J].
Desbordes, SC ;
Sanson, B .
DEVELOPMENT, 2003, 130 (25) :6245-6255
[8]   Proteoglycans in prostate cancer [J].
Edwards, Iris J. .
NATURE REVIEWS UROLOGY, 2012, 9 (04) :196-206
[9]   Glypicans: proteoglycans with a surprise [J].
Filmus, J ;
Selleck, SB .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (04) :497-501
[10]   Inactivation of Wnt Signaling by a Human Antibody That Recognizes the Heparan Sulfate Chains of Glypican-3 for Liver Cancer Therapy [J].
Gao, Wei ;
Kim, Heungnam ;
Feng, Mingqian ;
Phung, Yen ;
Xavier, Charles P. ;
Rubin, Jeffrey S. ;
Ho, Mitchell .
HEPATOLOGY, 2014, 60 (02) :576-587
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