New anti-HBV caryophyllane-type sesquiterpenoids from Euphorbia humifusa Willd

被引：21
|
作者：
Tian, Ying [1 ]
Sun, Li-Min [1 ]
Li, Bin [1 ]
Liu, Xi-Qiao [1 ]
Dong, Jun-Xing [1 ]
机构：
[1] Beijing Inst Radiat Med, Dept Pharmaceut Chem, Beijing 100850, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Euphorbia humifusa; Caryophllane; Sesquiterpenoid; Anti-HBV activity; GLYCOSIDES;
D O I：
10.1016/j.fitote.2010.10.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Activity-guided fractionation of Euphorbia humifusa for anti-HBV activity led to the isolation of two novel sesquiterpenoids, named humifusane A (1) and humifusane B (2). Their structures were elucidated by spectral data to show that they have a caryophyllane-type precursor structure. The two new sesquiterpenoids showed anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：251 / 254
页数：4
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