Synthesis of aminoisoquinolines via Rh-catalyzed [4+2] annulation of benzamidamides with vinylene carbonate

被引：40

作者：

Huang, Xin

Xu, Yingying

Li, Jianglian

Lai, Ruizhi

Luo, Yi

Wang, Qiantao

Yang, Zhongzhen ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Benzamidamide; Aminoisoquinolines; Vinylene carbonate; C-H Activation; Rh-catalyzed; C-H ACTIVATION; QUINOLINE N-OXIDES; METAL-FREE SYNTHESIS; BOND ACTIVATION; DIVERGENT COUPLINGS; SULFOXONIUM YLIDES; INTERNAL ALKYNES; IMIDAMIDES; MILD; FUNCTIONALIZATION;

D O I：

10.1016/j.cclet.2021.04.058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives. This Rh(III)-catalyzed [4 + 2] annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate. Additionally, the reaction features broad substrate scopes and good yields, only producing carbonate anion as byproduct. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页码：3518 / 3521

页数：4

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