Retrospective Cohort Study of Caveolin-1 Expression as Prognostic Factor in Unresectable Locally Advanced or Metastatic Pancreatic Cancer Patients

被引：3

作者：

Bittoni, Alessandro ^{[1
]}

Giampieri, Riccardo ^{[1
]}

Pecci, Federica ^{[1
]}

Pinterpe, Giada ^{[1
]}

Mandolesi, Alessandra ^{[2
]}

Del Prete, Michela ^{[3
]}

Zizzi, Antonio ^{[2
]}

Crocetti, Sonia ^{[1
]}

Liguori, Carolina ^{[1
]}

Mentrasti, Giulia ^{[1
]}

Cantini, Luca ^{[1
]}

Pellei, Chiara ^{[1
,4
]}

Bisonni, Renato ^{[3
]}

Scarpelli, Marina ^{[2
]}

Berardi, Rossana ^{[1
]}

机构：

[1] Univ Politecn Marche, Med Oncol Unit, Azienda Ospedaliero Univ Ospedali Riuniti Umberto, I-60126 Ancona, Italy

[2] Azienda Ospedaliero Univ Ospedali Riuniti Umberto, Dept Pathol Anat & Histopathol, I-60126 Ancona, Italy

[3] Osped A Murri, Med Oncol Unit, I-63900 Fermo, Italy

[4] Osped Madonna Soccorso, Med Oncol Unit, I-63074 San Benedetto Tronto, Italy

来源：

CURRENT ONCOLOGY | 2021年 / 28卷 / 05期

关键词：

Caveolin-1; pancreatic cancer; 1st line chemotherapy; prognosis; GEMCITABINE; FOLFIRINOX; SURVIVAL;

D O I：

10.3390/curroncol28050303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolin-1 (Cav-1) plays a key role in various neoplastic diseases and is upregulated in different cancers, including pancreatic ductal adenocarcinoma (PDAC). Furthermore, Cav-1 is critical for the uptake of albumin as well as nab-paclitaxel in PDAC cells. Here, we investigated the prognostic impact of Cav-1 expression in a cohort of 39 metastatic PDAC patients treated with different first-line chemotherapy regimens. We also assessed the predictive value of Cav-1 in patients treated with gemcitabine and nab-paclitaxel. Cav-1 expression was evaluated by immunohistochemistry staining in neoplastic and stromal cells, using metastatic sites or primary tumor tissue specimens. Higher levels of Cav-1 expression were associated with significantly worse overall survival (OS) and progression-free survival (PFS). No differences in OS were found between patients treated with gemcitabine + nab-paclitaxel vs. other chemotherapy options. Multivariate analysis for OS and PFS confirmed the independent prognostic role of Cav-1 expression. Our study evidenced a negative prognostic role of Cav-1 in patients affected by metastatic/locally advanced unresectable PDAC. Moreover, Cav-1 expression seems not to predict different response rates to different types of first-line treatment. Future prospective trials will be necessary to confirm the prognostic role of Cav-1 and explore Cav-1 specific inhibitors as a therapeutic option for advanced PDAC patients.

引用

页码：3525 / 3536

页数：12

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