Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

被引：58

作者：

Gutierrez, Laia ^{[1
,2
]}

Folch, Alexandre ^{[1
,2
]}

Rojas, Melina ^{[1
,2
]}

Cantero, Jose Luis ^{[3
,4
]}

Atienza, Mercedes ^{[3
,4
]}

Folch, Jaume ^{[1
,2
,4
]}

Camins, Antoni ^{[4
,5
,6
]}

Ruiz, Agustin ^{[4
,7
]}

Papandreou, Christopher ^{[2
,8
]}

Bullo, Monica ^{[1
,2
,8
]}

机构：

[1] Rovira & Virgili Univ, Nutr & Metab Disorders Res Grp, Dept Biochem & Biotechnol, Reus 43201, Spain

[2] Inst Hlth Pere Virgili IISPV, Nutr & Metab Disorders Res Grp, Reus 43204, Spain

[3] Pablo Olavide Univ, Lab Funct Neurosci, Seville 41013, Spain

[4] CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid 28031, Spain

[5] Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Fac Pharm & Food Sci, Barcelona 08028, Spain

[6] Univ Barcelona, Inst Neurociencies UBNeuro, Barcelona 08035, Spain

[7] Univ Int Catalunya UIC, ACE Alzheimer Ctr Barcelona, Barcelona 08028, Spain

[8] Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid 28029, Spain

来源：

NUTRIENTS | 2021年 / 13卷 / 11期

关键词：

diet; food; supplements; dietary interventions; cognitive impairment; healthy; subjective cognitive decline; Alzheimer's disease; PLACEBO-CONTROLLED TRIAL; POLYUNSATURATED FATTY-ACIDS; CORTICAL GLUCOSE-UPTAKE; OLDER-ADULTS; DOUBLE-BLIND; MEDITERRANEAN DIET; FISH-OIL; MULTIDOMAIN INTERVENTION; AMYLOID-BETA; DECLINE;

D O I：

10.3390/nu13113728

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.

引用

页数：40

共 125 条

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