Postpartum seizures after epidural analgesia: a patient with a mutation of the factor V Leiden and prothrombin gene

被引:2
作者
van Nordennen, Johannes [1 ]
Camu, Frederic [1 ]
机构
[1] Free Univ Brussels, Acad Hosp, Dept Anesthesiol, B-1090 Brussels, Belgium
关键词
analgesia; epidural; activated protein C resistance; factor V-Leiden mutation; postdural puncture headache; prothrombin-gene mutation G20210A; venous sinus thrombosis;
D O I
10.1016/j.jclinane.2007.02.014
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We report the case of a 27-year-old parturient who developed a headache within 12 hours of delivery and who subsequently seized. Further examination, including magnetic resonance imaging and computed tomographic scan, showed a partial thrombosis of a transversal venous sinus, the underlying cause being an activated protein C resistance caused by a heterozygote factor V Leiden mutation and heterozygote prothrombin-gene mutation G20210A. Seven months after delivery, the patient is in good health, showing no neurocognitive disability. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:549 / 550
页数:2
相关论文
共 10 条
  • [1] A case of late postpartum seizures after epidural analgesia
    Akerman, N
    Hall, W
    [J]. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2005, 14 (02) : 163 - 166
  • [2] MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C
    BERTINA, RM
    KOELEMAN, BPC
    KOSTER, T
    ROSENDAAL, FR
    DIRVEN, RJ
    DERONDE, H
    VANDERVELDEN, PA
    REITSMA, PH
    [J]. NATURE, 1994, 369 (6475) : 64 - 67
  • [3] Postpartum headaches: summary report of the National Obstetric Anaesthetic Database (NOAD) 1999
    Chan, TML
    Ahmed, E
    Yentis, SM
    Holdcroft, A
    [J]. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2003, 12 (02) : 107 - 112
  • [4] The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation
    De Stefano, V
    Martinelli, I
    Mannucci, PM
    Paciaroni, K
    Chiusolo, P
    Casorelli, I
    Rossi, E
    Leone, G
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) : 801 - 806
  • [5] KURKOWSKAJASTRZ.I, 2003, MED SCI MONITOR, V9, P41
  • [6] Neurological complications in obstetric regional anaesthesia
    Loo, CC
    Dahlgren, G
    Irestedt, L
    [J]. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2000, 9 (02) : 99 - 124
  • [7] Recurrent post-partum seizures after epidural blood patch
    Marfurt, D
    Lyrer, P
    Rüttimann, U
    Strebel, S
    Schneider, MC
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2003, 90 (02) : 247 - 250
  • [8] Paech M, 1996, Int J Obstet Anesth, V5, P43, DOI 10.1016/S0959-289X(96)80073-2
  • [9] Incidence and characteristics of failures in obstetric neuraxial analgesia and anesthesia: A retrospective analysis of 19,259 deliveries
    Pan, PH
    Bogard, TD
    Owen, MD
    [J]. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2004, 13 (04) : 227 - 233
  • [10] A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    Poort, SR
    Rosendaal, FR
    Reitsma, PH
    Bertina, RM
    [J]. BLOOD, 1996, 88 (10) : 3698 - 3703