Prospective Clinical Trial of Anti-CD19 CAR T Cells in Combination with Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia Shows a High Response Rate

被引：69

作者：

Gill, Saar I. ^{[1
]}

Vides, Vanessa ^{[2
]}

Frey, Noelle V. ^{[1
]}

Metzger, Susan ^{[3
]}

O'Brien, Megan ^{[3
]}

Hexner, Elizabeth ^{[4
]}

Mato, Anthony R. ^{[4
]}

Lacey, Simon F. ^{[3
]}

Melenhorst, J. Joseph ^{[3
]}

Pequignot, Edward ^{[3
]}

Gladney, Whitney Lynn ^{[3
]}

Hwang, Wei-Ting ^{[5
]}

Lamontagne, Anne

Davis, Megan ^{[3
]}

Byrd, John C. ^{[3
,6
]}

Schuster, Stephen J. ^{[4
]}

Siegel, Don L. ^{[7
,8
,9
]}

Isaacs, Randi E. ^{[10
]}

June, Carl H. ^{[3
,8
,11
,12
]}

Porter, David L. ^{[4
]}

机构：

[1] Univ Penn, Div Hematol & Oncol, Philadelphia, PA 19104 USA

[2] Penn State Univ, Coll Med, Hershey, PA USA

[3] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[4] Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[6] Ohio State Univ, Columbus, OH 43210 USA

[7] Univ Penn, Ctr Adv Cellular Therapies Transfus Med & Therape, Philadelphia, PA 19104 USA

[8] Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA

[9] Univ PA, Med Ctr, Philadelphia, PA USA

[10] Novartis Inst Biomed Res, Cambridge, MA USA

[11] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[12] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA

来源：

关键词：

D O I：

10.1182/blood-2018-99-115418

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

298

引用

页数：5