Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment

被引：17

作者：

Williams, AnnaLynn M. ^{[1
,2
,6
]}

van Wijngaarden, Edwin ^{[1
]}

Seplaki, Christopher L. ^{[1
]}

Heckler, Charles E. ^{[3
]}

Weber, Miriam T. ^{[4
]}

Barr, Paul M. ^{[2
,5
]}

Zent, Clive S. ^{[2
,5
]}

Janelsins, Michelle C. ^{[2
,3
]}

机构：

[1] Univ Rochester, Dept Publ Hlth Sci, Med Ctr, Rochester, NY 14642 USA

[2] Univ Rochester, James P Wilmot Canc Inst, Med Ctr, Rochester, NY 14642 USA

[3] Univ Rochester, Dept Surg, Med Ctr, Rochester, NY 14642 USA

[4] Univ Rochester, Dept Neurol, Med Ctr, Rochester, NY 14642 USA

[5] Univ Rochester, Dept Med, Med Ctr, Rochester, NY 14642 USA

[6] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

LEUKEMIA & LYMPHOMA | 2020年 / 61卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Chronic lymphocytic leukemia; cognitive impairment; chemotherapy; treatment naive; BREAST-CANCER; IMPAIRMENT; SURVIVORS; ASSOCIATIONS; MULTICENTER; PERFORMANCE; MANAGEMENT; UPDATE; SCALE;

D O I：

10.1080/10428194.2020.1728748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer-related cognitive impairment (CRCI) has not been objectively assessed in chronic lymphocytic leukemia (CLL). It is currently unclear how much of CRCI is attributable to disease, treatment, or both. We used CLL as a novel model to study the differential roles of disease and treatment in CRCI. One hundred and fifty CLL patients (100 treatment-naive and 50 chemotherapy-treated) including 84 patients with higher-risk of CLL progression completed objective neuropsychological tests. Sociodemographic-adjusted linear regression models examined cognitive outcomes in relation to risk and treatment. Higher-risk patients recalled two fewer words on a memory task (beta = -1.8, 95%CI -3.3,-0.3) and took 15 s longer on an executive function task (beta = 15.4, 95%CI 3.1, 27.6) than lower-risk patients, independent of treatment. Treated patients reported greater cognitive difficulties than treatment-naive patients (beta = -6.1, 95%CI -10.1, -2.2) but did not perform worse on objective measures. Higher-risk patients experienced impairments in executive function and memory suggesting that disease biology contributes to CRCI independent of treatment.

引用

页码：1627 / 1635

页数：9

共 35 条

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