Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives

被引：10

作者：

Vicente, Esther ^{[1
]}

Villar, Raquel ^{[1
]}

Burguete, Asuncion ^{[1
]}

Solano, Beatriz ^{[1
]}

Ancizu, Saioa ^{[1
]}

Perez-Silanes, Silvia ^{[1
]}

Aldana, Ignacio ^{[1
]}

Monge, Antonio ^{[1
]}

机构：

[1] Univ Navarra, CIFA, Unidad Invest & Desarrollo Medicamentos, E-31080 Pamplona, Spain

来源：

MOLECULES | 2008年 / 13卷 / 01期

关键词：

quinoxaline; N-oxides; Beirut reaction; gaseous ammonia;

D O I：

10.3390/molecules13010086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy-3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced by a methoxy group when dissolved in an ammonia saturated solution of methanol was clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous ammonia.

引用

收藏

页码：86 / 95

页数：10

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