CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis Setting the Stage for a New Chapter in Therapeutic Targeting

被引：63

作者：

Weber, Christian ^{[1
,2
,3
]}

von Hundelshausen, Philipp ^{[1
,2
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Pettenkoferstr 9, D-80336 Munich, Germany

[2] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany

[3] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands

来源：

CIRCULATION RESEARCH | 2017年 / 121卷 / 10期

关键词：

C-REACTIVE PROTEIN; HEMATOPOIESIS; WOMEN;

D O I：

10.1161/CIRCRESAHA.117.311984

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The CANTOS trial (Canakinumab Anti-Inflammatory Thrombosis Outcome Study) provides intriguing support for the inflammatory hypothesis of atherosclerosis and cancer in man, demonstrating diverse clinical benefits of inhibiting IL (interleukin)-1 beta for cardiovascular events and lung cancer. Limited effects on cardiovascular mortality and safety concerns raised by a higher incidence of fatal infection warrant further studies to identify patient subgroups which profit most from anti-inflammatory therapy and a careful pursuit of alternative targets.

引用

页码：1119 / +

页数：4

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