Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals

被引：25
作者：
Tokura, Yoshiki [1 ]
Kobayashi, Miwa [1 ]
Kabashima, Kenji [1 ]
机构：
[1] Univ Occupat & Environm Hlth, Dept Dermatol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan
来源：
EXPERIMENTAL DERMATOLOGY | 2008年 / 17卷 / 02期
关键词：
antibiotic; antifungal; antihistamine; chemokine; epidermis;
D O I：
10.1111/j.1600-0625.2007.00657.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Growing evidence has demonstrated that chemokines released from epidermal cells control inflammatory skin diseases. Keratinocytes elaborate both Th1- and Th2-associated chemokines, although the former is more abundantly produced than the latter. Downmodulation of keratinocyte production of chemokines is one of the therapeutic approaches for cutaneous inflammatory disorders. Recent observations have shown that keratinocyte chemokine production can be modulated by well-used drugs, including antihistamines, antibiotics and antifungals. Utilization of the beneficial side effects of these drugs may by clinically valuable.
引用
收藏
页码：81 / 90
页数：10
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