Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals

被引：25
作者：
Tokura, Yoshiki [1 ]
Kobayashi, Miwa [1 ]
Kabashima, Kenji [1 ]
机构：
[1] Univ Occupat & Environm Hlth, Dept Dermatol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan
来源：
EXPERIMENTAL DERMATOLOGY | 2008年 / 17卷 / 02期
关键词：
antibiotic; antifungal; antihistamine; chemokine; epidermis;
D O I：
10.1111/j.1600-0625.2007.00657.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Growing evidence has demonstrated that chemokines released from epidermal cells control inflammatory skin diseases. Keratinocytes elaborate both Th1- and Th2-associated chemokines, although the former is more abundantly produced than the latter. Downmodulation of keratinocyte production of chemokines is one of the therapeutic approaches for cutaneous inflammatory disorders. Recent observations have shown that keratinocyte chemokine production can be modulated by well-used drugs, including antihistamines, antibiotics and antifungals. Utilization of the beneficial side effects of these drugs may by clinically valuable.
引用
收藏
页码：81 / 90
页数：10
相关论文
共 89 条
  • [1] Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection
    Abeyama, K
    Kawahara, K
    Lino, S
    Hamada, T
    Arimura, S
    Matsushita, K
    Nakajima, T
    Maruyama, I
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (05) : 908 - 915
  • [2] IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines
    Albanesi, C
    Scarponi, C
    Sebastiani, S
    Cavani, A
    Federici, M
    De Pità, O
    Puddu, P
    Girolomoni, G
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (03) : 1395 - 1402
  • [3] Albanesi C, 1998, CLIN EXP ALLERGY, V28, P101
  • [4] Albanesi C, 2001, J LEUKOCYTE BIOL, V70, P617
  • [5] In vitro investigations with the histamine H1 receptor antagonist, epinastine (WAL 801 CL), on isolated human allergic effector cells
    Amon, U
    Gibbs, BF
    Buss, G
    Nitschke, M
    [J]. INFLAMMATION RESEARCH, 2000, 49 (03) : 112 - 116
  • [6] Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis
    Annels, NE
    da Costa, CET
    Prins, FA
    Willemze, A
    Hogendoorn, PCW
    Egeler, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) : 1385 - 1390
  • [7] KETOCONAZOLE IN ATOPIC-DERMATITIS - THERAPEUTIC RESPONSE IS CORRELATED WITH DECREASE IN SERUM IGE
    BACK, O
    SCHEYNIUS, A
    JOHANSSON, SGO
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 1995, 287 (05) : 448 - 451
  • [8] Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists
    Bakker, RA
    Wieland, K
    Timmerman, H
    Leurs, R
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 387 (01) : R5 - R7
  • [9] Histamine H1-receptor activation of nuclear factor-κB:: Roles for Gβγ- and Gαq/11-subunits in constitutive and agonist-mediated signaling
    Bakker, RA
    Schoonus, SBJ
    Smit, MJ
    Timmerman, H
    Leurs, R
    [J]. MOLECULAR PHARMACOLOGY, 2001, 60 (05) : 1133 - 1142
  • [10] KERATINOCYTES AS INITIATORS OF INFLAMMATION
    BARKER, JNWN
    MITRA, RS
    GRIFFITHS, CEM
    DIXIT, VM
    NICKOLOFF, BJ
    [J]. LANCET, 1991, 337 (8735) : 211 - 214
123456789