Immunotherapy: a new alternative treatment for head and neck squamous cell carcinoma

被引：1

作者：

Bron, Luc ^{[1
]}

Romero, Pedro ^{[2
]}

机构：

[1] CHU Vaudois, Serv ORL Chirurg Cervicofaciale, CH-1011 Lausanne, Switzerland

[2] Inst Ludwig Rech Canc Epalinges, Div Onco Immunol, Lausanne, Switzerland

来源：

BULLETIN DU CANCER | 2007年 / 94卷 / 09期

关键词：

head and neck; squamous cell carcinoma; immunotherapy;

D O I：

10.1684/bdc.2007.0426

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the past decades, prognosis of head and neck squamous cell carcinoma (HNSCC) has not improved even though treatment has made substantial progress, Since the description of immune response against some cancers, antitumoral immunotherapy has been studied to be used as adjunctive treatment in various cancer types. This article review contributions made in the field of immunotherapy on HNSCC in the past few years, It appears that this approach may play an important role in the treatment of head and neck squamous cell carcinoma. Among various TAAs, cancer testis antigens family may be promising candidates for specific immune therapy in HNSCC. Ongoing studies will confirm whether expression CTAs generate an immune response in clinical vaccine trials.

引用

页码：793 / 797

页数：5

共 37 条

[1] EGFR-targeting monoclonal antibodies in head and neck cancer [J].

Astsaturov, Igor ;

Cohen, Roger B. ;

Harari, Paul M. .

CURRENT CANCER DRUG TARGETS, 2006, 6 (08) :691-710

[2]

Balz V, 2003, CANCER RES, V63, P1188

[3] Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer [J].

Bernier, J ;

Domenge, C ;

Ozsahin, M ;

Matuszewska, K ;

Lefèbvre, JL ;

Greiner, RH ;

Giralt, J ;

Maingon, P ;

Rolland, F ;

Bolla, M ;

Cognetti, F ;

Bourhis, J ;

Kirkpatrick, A ;

van Glabbeke, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (19) :1945-1952

[4] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[5]

BOON T, 1994, ANNU REV IMMUNOL, V12, P337, DOI 10.1146/annurev.iy.12.040194.002005

[6] Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: Consensus, controversy, and conundrum [J].

Brizel, DM ;

Esclamado, R .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (17) :2612-2617

[7] Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma [J].

Calais, G ;

Alfonsi, M ;

Bardet, E ;

Sire, C ;

Germain, T ;

Bergerot, P ;

Rhein, B ;

Tortochaux, J ;

Oudinot, P ;

Bertrand, P .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (24) :2081-2086

[8] A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening [J].

Chen, YT ;

Scanlan, MJ ;

Sahin, U ;

Tureci, O ;

Gure, AO ;

Tsang, SL ;

Williamson, B ;

Stockert, E ;

Pfreundschuh, M ;

Old, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1914-1918

[9] Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer [J].

Forastiere, AA ;

Goepfert, H ;

Maor, M ;

Pajak, TF ;

Weber, R ;

Morrison, W ;

Glisson, B ;

Trotti, A ;

Ridge, JA ;

Chao, C ;

Peters, G ;

Lee, DJ ;

Leaf, A ;

Ensley, J ;

Cooper, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (22) :2091-2098

[10] Evidence for a causal association between human papillomavirus and a subset of head and neck cancers [J].

Gillison, ML ;

Koch, WM ;

Capone, RB ;

Spafford, M ;

Westra, WH ;

Wu, L ;

Zahurak, ML ;

Daniel, RW ;

Viglione, M ;

Symer, DE ;

Shah, KV ;

Sidransky, D .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (09) :709-720

← 1 2 3 4 →