Psoriasis patients with psoriasis Area and Severity Index (PASI) 90 response achieve greater health-related quality-of-life improvements than those with PASI 75-89 response: results from two phase 3 studies of secukinumab

被引：46

作者：

Elewski, Boni E. ^{[1
]}

Puig, Lluis ^{[2
]}

Mordin, Margaret ^{[3
]}

Gilloteau, Isabelle ^{[4
]}

Sherif, Bintu ^{[5
]}

Fox, Todd ^{[4
]}

Gnanasakthy, Ari ^{[5
]}

Papavassilis, Charis ^{[4
]}

Strober, Bruce E. ^{[6
,7
]}

机构：

[1] Univ Alabama Birmingham, Birmingham, AL USA

[2] Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona, Spain

[3] RTI Hlth Solut, Ann Arbor, MI USA

[4] Novartis Pharma AG, Basel, Switzerland

[5] RTI Hlth Solut, Res Triangle Pk, NC USA

[6] Univ Connecticut, Hlth Ctr, Farmington, CT USA

[7] Prob Med Res, Waterloo, ON, Canada

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2017年 / 28卷 / 06期

关键词：

Psoriasis; secukinumab; patient-reported outcome; DLQI; PASI; IGA; SEVERE PLAQUE PSORIASIS; BIOLOGICAL THERAPIES; CONTROLLED-TRIAL; DOUBLE-BLIND; MODERATE; EFFICACY; SAFETY; DLQI; USABILITY; OUTCOMES;

D O I：

10.1080/09546634.2017.1294727

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: The emergence of new biological therapies showing high and sustained level of Psoriasis Area and Severity Index (PASI) 90 response has provided the possibility of both greater skin clearance and increased quality of life (QOL). Objective: To evaluate the association of greater response in skin clearance with improvements in skinrelated QOL up to 52 weeks. Methods: Subjects achieving various levels of skin clearance (PASI 90-100 or PASI 75-89) and Dermatology Life Quality Index (DLQI) (0/1) response were compared using ERASURE and FIXTURE trial data. Similar analyses with IGA ratings of Clear or Almost Clear were performed. Results: Significantly more PASI 90-100 responders at week 12 had DLQI 0/1 response than PASI 75-89 (69.4% vs. 47.1%; p<. 001) and sustained DLQI 0/1 response at week 52 (74.0% vs. 56.7%; p<. 001). IGA results were similar. Conclusions: These results show that PASI 90-100 is a relevant therapeutic goal in moderate to severe psoriasis compared to PASI 75-89 when considering patients' QOL.

引用

页码：492 / 499

页数：8

共 30 条

[1] Assessing the overall benefit of a medication: cumulative benefit of secukinumab over time in patients with moderate-to-severe plaque psoriasis [J].