A Short Asymmetric Route to the Bromophycolide A and D Skeleton

被引：16

作者：

Lin, Hongkun ^{[1
]}

Pochapsky, Susan S. ^{[1
]}

Krauss, Isaac J. ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

关键词：

ALGA CALLOPHYCUS-SERRATUS; BIOGENETIC-TYPE SYNTHESIS; INDUCED POLYENE CYCLIZATIONS; BIOMIMETIC TOTAL-SYNTHESIS; BROMINATIVE CYCLIZATION; ELECTROPHILIC BROMINATION; BENZOIC ANHYDRIDE; ACCEPTOR OLEFINS; HALONIUM IONS; DERIVATIVES;

D O I：

10.1021/ol200099n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the bromophycolide D ring system has been achieved in seven steps from a known geranylgeranylated benzoate, via bromonium-promoted transannular cyclization of a macrocyclic intermediate.

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收藏

页码：1222 / 1225

页数：4

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