Flavanonol Glycosides from the Stems of Myrsine seguinii and Their Neuroprotective Activities

被引：2
作者：
Lee, Hee-Ju [1 ,2 ]
Park, Eun-Jin [1 ]
Lee, Ba-Wool [1 ]
Cho, Hyo-Moon [1 ]
Thi-Linh-Giang Pham [3 ]
Quynh-Hoa Hoang [3 ]
Pan, Cheol-Ho [2 ]
Oh, Won-Keun [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Korea Bioact Nat Mat Bank, Res Inst Pharmaceut Sci, Seoul 08826, South Korea
[2] Korea Inst Sci & Technol, Nat Prod Informat Res Ctr, Gangeung 25451, South Korea
[3] Hanoi Univ Pharm, Dept Bot, Hanoi 100000, Vietnam
来源：
PHARMACEUTICALS | 2021年 / 14卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
Myrsine seguinii; Primulaceae; Alzheimer's disease; flavanonol glycoside; molecular networking; neuroprotective activity; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ACID-B; LEAVES; ROXBURGHIANA; GALANTAMINE;
D O I：
10.3390/ph14090911
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The accumulation of amyloid beta (A beta) peptides is common in the brains of patients with Alzheimer's disease, who are characterized by neurological cognitive impairment. In the search for materials with inhibitory activity against the accumulation of the A beta peptide, seven undescribed flavanonol glycosides (1-7) and five known compounds (8-12) were isolated from stems of Myrsine seguinii by HPLC-qTOF MS/MS-based molecular networking. Interestingly, this plant has been used as a folk medicine for the treatment of various inflammatory conditions. The chemical structures of the isolated compounds (1-12) were elucidated based on spectroscopic data, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS) and electronic circular dichroism (ECD) data. Compounds 2, 6 and 7 showed neuroprotective activity against A beta-induced cytotoxicity in A beta(42)-transfected HT22 cells.
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页数：15
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