Clinical Targeting of Altered Metabolism in High-Grade Glioma

被引：5

作者：

Scott, Andrew J. ^{[1
]}

Lyssiotis, Costas A. ^{[2
,3
]}

Wahl, Daniel R. ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiat Oncol, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol & Integat Physiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Rogel Canc Ctr, Dept Internal Med, Div Gastroentrol & Hepatol, Ann Arbor, MI 48109 USA

来源：

CANCER JOURNAL | 2021年 / 27卷 / 05期

关键词：

Astrocytoma; glioblastoma; isocitrate dehydrogenase; metabolism; oligodendroglioma; purines; radiation; CENTRAL-NERVOUS-SYSTEM; BRAIN-TUMOR; MUTANT IDH1; ADJUVANT TEMOZOLOMIDE; HUMAN GLIOBLASTOMA; PURINE SYNTHESIS; CANCER-CELLS; STEM-CELLS; PHASE-II; RADIOTHERAPY;

D O I：

10.1097/PPO.0000000000000550

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-grade gliomas are among the deadliest of all cancers despite standard treatments, and new therapeutic strategies are needed to improve patient outcome. Targeting the altered metabolic state of tumors with traditional chemotherapeutic agents has a history of success, and our increased understanding of cellular metabolism in the past 2 decades has reinvigorated the concept of novel metabolic therapies in brain tumors. Here we highlight metabolic alterations in advanced gliomas and their translation into clinical trials using both novel agents and already established drugs repurposed for cancer treatment in an effort to improve outcome for these deadly diseases.

引用

页码：386 / 394

页数：9

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