Monoclonal antibodies used as prophylactic, therapeutic and diagnostic agents

被引：1

作者：

Chakhtoura, Marita ^{[1
]}

Abdelnoor, Alexander M. ^{[1
]}

机构：

[1] Amer Univ Beirut, Dept Microbiol & Immunol, Fac Med, Beirut 11972020, Lebanon

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2010年 / 32卷 / 04期

关键词：

Monoclonal antibodies; preparation; mechanism of action; uses; drawbacks; COLON-CANCER; PREVENTION; REJECTION; IMMUNOPURIFICATION; TRANSPLANTATION; CHEMOTHERAPY; INFECTION; RITUXIMAB; LYMPHOMA; DISEASE;

D O I：

10.3109/08923971003646597

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. The preparation, mechanism of action, uses, and possible adverse effects of most of the available monoclonal antibodies used as prophylactic, therapeutic, and diagnostic agents are reviewed.</.

引用

页码：533 / 542

页数：10

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