Mimicking the Active Sites of Organophosphorus Hydrolase on the Backbone of Graphene Oxide to Destroy Nerve Agent Simulants

被引：51

作者：

Ma, Xuejuan ^{[1
,2
]}

Zhang, Lin ^{[1
,2
]}

Xia, Mengfan ^{[1
,2
]}

Li, Shuangqin ^{[1
,2
]}

Zhang, Xiaohong ^{[1
,2
]}

Zhang, Yaodong ^{[1
,2
]}

机构：

[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Analyt Chem Life Sci Shaanxi Prov, Xian 710062, Peoples R China

[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 25期

基金：

中国国家自然科学基金;

关键词：

biomimetic catalyst; organophosphorus hydrolase; nerve agents; graphene oxide; synergistic effect; CATALYTIC-ACTIVITY; QUANTUM DOTS; DEGRADATION; PHOSPHOTRIESTERASE; NANOPARTICLES; PHOTOCATALYSIS; HYDROLYSIS; MECHANISM; POLYMERS;

D O I：

10.1021/acsami.7b07770

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Recent global military events, such as the conflict in Syria, have emphasized the need to find effective strategies to rapidly destroy organophosphorus-based nerve agents. In this work, we designed active site-engineered graphene oxide (GO) via polymerization (polymer bead-GOs) as organophosphorus hydrolase (OPH) mimetic hotspots for the rapid degradation of nerve agents. This hybrid catalyst has a high total turnover frequency value of 0.65 s(-1) and good stability (94.8% activity maintained after 5 cycles). Mechanism investigations suggested that the high catalytic performance could be attributed to the synergistic effect among the clusters of imidazole and the presence of - COOH groups on the GO surface and Zn2+.

引用

页码：21089 / 21093

页数：5

共 29 条

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