A small-molecule antagonist of the hedgehog signaling pathway

被引：68
作者：
Lee, Jongkook
Wu, Xu
di Magliano, Marina Pasca
Peters, Eric C.
Wang, Yan
Hong, Jiyong
Hebrok, Metthias
Din, Sheng
Cho, Charles Y.
Schultz, Peter G.
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
[4] Univ Calif San Francisco, Dept Med, Ctr Diabet, San Francisco, CA 94143 USA
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 16期
关键词：
D O I：
10.1002/cbic.200700403
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK1 84 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.
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收藏
页码：1916 / +
页数：5
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