Mucosal-associated invariant T cells in natural immunity and vaccination against infectious diseases in humans

被引：6

作者：

Masina, Nomawethu ^{[1
]}

Bekiswa, Abulele ^{[1
]}

Shey, Muki ^{[1
,2
]}

机构：

[1] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med IDM, Wellcome Ctr Infect Dis Res Africa CIDRI Africa, Cape Town, South Africa

[2] Univ Cape Town, Fac Hlth Sci, Dept Med, Cape Town, South Africa

来源：

CURRENT OPINION IN IMMUNOLOGY | 2021年 / 71卷

基金：

新加坡国家研究基金会; 英国惠康基金;

关键词：

MAIT CELLS; MEMORY; HETEROGENEITY; GENERATION; ACTIVATION;

D O I：

10.1016/j.coi.2021.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal-associated invariant T (MAIT) cells are subsets of T cells abundant in human mucosal tissues and in blood. These cells are activated directly by cytokines or by vitamin B metabolites antigen presentation. MAIT cells possess antimicrobial potential against viruses and bacteria through production of cytokines and cytotoxic molecules. MAIT cells generally reduce in numbers and function during viral and bacterial infections/diseases. Mice and humans lacking MAIT cells cannot effectively control bacterial infections. MAIT cells respond rapidly to infections and are rapidly recruited to the site of vaccination or infection including the lungs where they can be involved in controlling local inflammation. These characteristics of MAIT cells offer them a unique potential to be explored as potential targets for vaccines.

引用

页码：1 / 5

页数：5

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