Glucocorticoids in the control of neuroinflammation

被引：69

作者：

Tischner, Denise ^{[1
]}

Reichardt, Holger M. ^{[1
]}

机构：

[1] Univ Gottingen, Sch Med, Dept Cellular & Mol Immunol, D-37073 Gottingen, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2007年 / 275卷 / 1-2期

关键词：

glucocorticoids; multiple sclerosis; experimental autoimmune encephalomyelitis; apoptosis; blood-brain barrier;

D O I：

10.1016/j.mce.2007.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glucocorticoids are a class of steroid hormones that are endowed with profound anti-inflammatory and immunosuppressive activities. Endogenous glucocorticoids are key players in the modulation of the immune system and establish an endocrine basis of many inflammatory diseases. In addition, synthetic glucocorticoids are amongst the most commonly prescribed drugs worldwide for the treatment of autoimmune disorders. In this review we summarize our present knowledge on the mechanisms by which glucocorticoids impact on multiple sclerosis (MS), a highly prevalent neuroinflammatory disease, and its animal model experimental autoimmune encephalomyelitis (EAE). In spite of the new methodologies that have become available during recent years, we are still far from a comprehensive picture of the mechanism by which glucocorticoids control neuroinflammation. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：62 / 70

页数：9

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