COVID-19-associated atypical hemolytic uremic syndrome and use of Eculizumab therapy

被引:14
作者
Gill, Jasmeet [1 ]
Hebert, Christopher Alan [2 ]
Colbert, Gates Burton [2 ]
机构
[1] Baylor Univ, Med Ctr Dallas, 3500 Gaston Ave,Barnett Tower,Ste 904, Dallas, TX 75246 USA
[2] Baylor Univ, Div Nephrol, Med Ctr Dallas, Dallas, TX 75246 USA
关键词
Thrombotic microangiopathy; COVID-19; Eculizumab; Acute kidney injury; THROMBOTIC MICROANGIOPATHY; PATIENT;
D O I
10.1007/s40620-021-01125-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
There is a high incidence of acute kidney injury with COVID-19 infections. The etiologies of acute kidney injury could be ischemic acute tubular necrosis or a complex process of complement activation leading to thrombotic microangiopathy. We present a case of 32-year-old Hispanic male with a history of heart transplant, admitted with COVID-19 and atypical hemolytic uremic syndrome, which was successfully treated with Eculizumab.
引用
收藏
页码:317 / 321
页数:5
相关论文
共 15 条
[1]   Toddler With New Onset Diabetes and Atypical Hemolytic-Uremic Syndrome in the Setting of COVID-19 [J].
Alizadeh, Faraz ;
O'Halloran, Amanda ;
Alghamdi, Areej ;
Chen, Charlotte ;
Trissal, Maria ;
Traum, Avram ;
DeCourcey, Danielle .
PEDIATRICS, 2021, 147 (02)
[2]   Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology [J].
Batlle, Daniel ;
Soler, Maria Jose ;
Sparks, Matthew A. ;
Hiremath, Swapnil ;
South, Andrew M. ;
Welling, Paul A. ;
Swaminathan, Sundararaman .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (07) :1380-1383
[3]  
Diao B., 2020, DIAGNOSIS ACUTE RESP, DOI [10.1101/2020.03.04.20031120, 10.1101]
[4]  
Diurno F, 2020, EUR REV MED PHARMACO, V24, P4040, DOI 10.26355/eurrev_202004_20875
[5]   Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis [J].
Gralinski, Lisa E. ;
Sheahan, Timothy P. ;
Morrison, Thomas E. ;
Menachery, Vineet D. ;
Jensen, Kara ;
Leist, Sarah R. ;
Whitmore, Alan ;
Heise, Mark T. ;
Baric, Ralph S. .
MBIO, 2018, 9 (05)
[6]  
Hirsch JS, 2020, KIDNEY INT, V98, P209, DOI 10.1016/j.kint.2020.05.006
[7]   Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection [J].
Ip, WKE ;
Chan, KH ;
Law, HKW ;
Tso, GHW ;
Kong, EKP ;
Wong, WHS ;
To, YF ;
Yung, RWH ;
Chow, EY ;
Au, KL ;
Chan, EYT ;
Lim, W ;
Jensenius, JC ;
Turner, MW ;
Peiris, JSM ;
Lau, YL .
JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (10) :1697-1704
[8]   Thrombotic microangiopathy in a patient with COVID-19 [J].
Jhaveri, Kenar D. ;
Meir, Lea R. ;
Chang, Bessy Suyin Flores ;
Parikh, Rushang ;
Wanchoo, Rimda ;
Barilla-LaBarca, Maria Louise ;
Bijol, Vanesa ;
Hajizadeh, Negin .
KIDNEY INTERNATIONAL, 2020, 98 (02) :509-512
[9]  
Li H, 2020, HIGHLY PATHOGENIC CO, DOI [10.1101/2020.03.29.20041962, DOI 10.1101/2020.03.29.20041962]
[10]   Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases [J].
Magro, Cynthia ;
Mulvey, J. Justin ;
Berlin, David ;
Nuovo, Gerard ;
Salvatore, Steven ;
Harp, Joanna ;
Baxter-Stoltzfus, Amelia ;
Laurence, Jeffrey .
TRANSLATIONAL RESEARCH, 2020, 220 :1-13