Vascular Endothelial Growth Factor Mimetic Peptide and Parathyroid Hormone (1-34) Delivered via a Blue-Light-Curable Hydrogel Synergistically Accelerate Bone Regeneration

被引：15

作者：

Wang, Guiyan ^{[1
,2
]}

Yuan, Ning ^{[3
,4
]}

Li, Ningyu ^{[5
]}

Wei, Qijia ^{[3
,4
]}

Qian, Yuping ^{[6
]}

Zhang, Jun ^{[3
,4
]}

Qin, Man ^{[1
,2
]}

Wang, Yuguang ^{[1
,2
]}

Dong, Suwei ^{[3
,4
]}

机构：

[1] Peking Univ Sch & Hosp Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Natl Clin Res Ctr Oral Dis, Beijing Key Lab Digital Stomatol, Beijing 100081, Peoples R China

[2] Peking Univ Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Chem Biol Ctr, Beijing 100191, Peoples R China

[4] Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[5] Jilin Univ Sch & Hosp Stomatol, Dept Oral Comprehens Treatment, Changchun 130021, Peoples R China

[6] Jilin Univ Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2022年 / 14卷 / 31期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

mimetic peptide; PTH(1-34); covalent functionalization; blue-light-curable hydrogel; bone regeneration; BIOMATERIALS; ANGIOGENESIS; MATRIX;

D O I：

10.1021/acsami.2c06159

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Safe and effective biomaterials are in urgent clinical need for tissue regeneration and bone repair. While numerous advances have been made on hydrogels promoting osteogenesis in bone formation, co stimulation of the angiogenic pathways in this process remains to be exploited. Here, we have developed a gelatin-based blue-light-curable hydrogel system, functionalized with an angiogenic vascular endothelial growth factor (VEGF) mimetic peptide, KLTWQELYQLKYKGI (KLT), and an osteoanabolic peptide, parathyroid hormone (PTH) 1-34. We have discovered that the covalent modification of gelatin scaffold with peptides can modulate the physical properties and biological activities of the produced hydrogels. Furthermore, we have demonstrated that those two peptides orchestrate synergistically and promote bone regeneration in a rat cranial bone defect model with remarkable efficacy. This dual-peptide-functionalized hydrogel system may serve as a promising lead to functional biomaterials in bone repair and tissue engineering.

引用

页码：35319 / 35332

页数：14

共 52 条

[1] Bone healing induced by local delivery of an engineered parathyroid hormone prodrug [J].