Overview of microRNA-199a Regulation in Cancer

被引：68

作者：

Wang, Qiwen ^{[1
,2
]}

Ye, Bingyu ^{[1
,2
]}

Wang, Ping ^{[1
,2
]}

Yao, Fenjie ^{[1
,2
]}

Zhang, Chunyan ^{[1
,2
]}

Yu, Guoying ^{[1
,2
]}

机构：

[1] Henan Normal Univ, Coll Life Sci, Henan Int Joint Lab Pulm Fibrosis, Xinxiang 453007, Henan, Peoples R China

[2] Henan Normal Univ, Coll Life Sci, State Key Lab Cell Differentiat & Regulat, Xinxiang 453007, Henan, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

关键词：

microRNA-199a; target genes; carcinoma; biomarker; regulatory mechanisms; CELL-PROLIFERATION; DOWN-REGULATION; MICRO-RNAS; MIR-199A-5P; AUTOPHAGY; TARGET; IDENTIFICATION; SUPPRESSES; EXPRESSION; CISPLATIN;

D O I：

10.2147/CMAR.S231971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.

引用

页码：10327 / 10335

页数：9

共 71 条

[1] MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation [J].

Alexander, M. S. ;

Kawahara, G. ;

Motohashi, N. ;

Casar, J. C. ;

Eisenberg, I. ;

Myers, J. A. ;

Gasperini, M. J. ;

Estrella, E. A. ;

Kho, A. T. ;

Mitsuhashi, S. ;

Shapiro, F. ;

Kang, P. B. ;

Kunkel, L. M. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (09) :1194-1208

[2] Extracellular matrix-derived extracellular vesicles promote cardiomyocyte growth and electrical activity in engineered cardiac atria [J].

An, Minae ;

Kwon, Kihwan ;

Park, Junbeom ;

Ryu, Dong-Ryeol ;

Shin, Jung-A. ;

Kang, Jihee Lee ;

Choi, Ji Ha ;

Park, Eun-Mi ;

Lee, Kyung Eun ;

Woo, Minna ;

Kim, Minsuk .

BIOMATERIALS, 2017, 146 :49-59

[3] MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potential [J].

Ballabio, Erica ;

Mitchell, Tracey ;

van Kester, Marloes S. ;

Taylor, Stephen ;

Dunlop, Heather M. ;

Chi, Jianxiang ;

Tosi, Isabella ;

Vermeer, Maarten H. ;

Tramonti, Daniela ;

Saunders, Nigel J. ;

Boultwood, Jacqueline ;

Wainscoat, James S. ;

Pezzella, Francesco ;

Whittaker, Sean J. ;

Tensen, Cornelius P. ;

Hatton, Christian S. R. ;

Lawrie, Charles H. .

BLOOD, 2010, 116 (07) :1105-1113

[4] Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11) [J].

Byrnes, Kimberly A. ;

Phatak, Pornima ;

Mansour, Daniel ;

Xiao, Lan ;

Zou, Tongtong ;

Rao, Jaladanki N. ;

Turner, Douglas J. ;

Wang, Jian-Ying ;

Donahue, James M. .

ONCOTARGET, 2016, 7 (08) :8756-8770

[5] miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1 [J].

Cardenas, Christian Lacks Lino ;

Henaoui, Imene Sarah ;

Courcot, Elisabeth ;

Roderburg, Christoph ;

Cauffiez, Christelle ;

Aubert, Sebastien ;

Copin, Marie-Christine ;

Wallaert, Benoit ;

Glowacki, Francois ;

Dewaeles, Edmone ;

Milosevic, Jadranka ;

Maurizio, Julien ;

Tedrow, John ;

Marcet, Brice ;

Lo-Guidice, Jean-Marc ;

Kaminski, Naftali ;

Barbry, Pascal ;

Luedde, Tom ;

Perrais, Michael ;

Mari, Bernard ;

Pottier, Nicolas .

PLOS GENETICS, 2013, 9 (02)

[6] Serum and Extracellular Vesicle MicroRNAs miR-423, miR-199, and miR-93☆ As Biomarkers for Acute Graft-wersus-Host Disease [J].

Crossland, Rachel E. ;

Norden, Jean ;

Juric, Mateja Kralj ;

Pearce, Kim F. ;

Lendrem, Clare ;

Bibby, Louis A. ;

Collin, Matthew ;

Greinix, Hildegard T. ;

Dickinson, Anne M. .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[7] Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5′ Untranslated Region [J].

Da Sacco, Letizia ;

Masotti, Andrea .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (01) :480-495

[8] MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α [J].

Ding, Gang ;

Huang, Gang ;

Liu, He-dai ;

Liang, Hong-xiang ;

Ni, Yu-feng ;

Ding, Zhao-heng ;

Ni, Guo-ying ;

Hua, Hong-wei .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 384 (1-2) :173-180

[9] Circulating miRNAs in nontumoral liver diseases [J].

do Amaral, Alex Evangelista ;

Cisilotto, Julia ;

Creczynski-Pasa, Tania Beatriz ;

Schiavon, Leonardo de Lucca .

PHARMACOLOGICAL RESEARCH, 2018, 128 :274-287

[10] miR-199a-3p and miR-214-3p improve the overall survival prediction of muscle-invasive bladder cancer patients after radical cystectomy [J].

Ecke, Thorsten H. ;

Stier, Katja ;

Weickmann, Sabine ;

Zhao, Zhongwei ;

Buckendahl, Laura ;

Stephan, Carsten ;

Kilic, Ergin ;

Jung, Klaus .

CANCER MEDICINE, 2017, 6 (10) :2252-2262

← 1 2 3 4 5 6 7 8 →