New insight into GABAergic neurons in the hypothalamic feeding regulation

被引：42
作者：
Suyama, Shigetomo [1 ]
Yada, Toshihiko [1 ,2 ]
机构：
[1] Jichi Med Univ, Sch Med, Div Integrat Physiol, Dept Physiol, 3311-1 Yakushiji, Shimotsuke, Tochigi 3200498, Japan
[2] Kansai Elect Power Med Res Inst, Chuou Ku, 1-5-6 Minatojimaminamimachi, Kobe, Hyogo 6500047, Japan
来源：
JOURNAL OF PHYSIOLOGICAL SCIENCES | 2018年 / 68卷 / 06期
关键词：
Hypothalamus; Food intake; GABAergic neurons; NPY/AgRP neruons; MELANIN-CONCENTRATING HORMONE; Y-CONTAINING NEURONS; NEUROPEPTIDE-Y; PROOPIOMELANOCORTIN NEURONS; ARCUATE NUCLEUS; POMC NEURONS; BODY-WEIGHT; FOOD-INTAKE; PARAVENTRICULAR NUCLEUS; AGRP NEURONS;
D O I：
10.1007/s12576-018-0622-8
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other GABAergic neurons act as an orexigenic. Here, we review the progress of studies on hypothalamic GABAergic neurons distributed in ARC, dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH). Three advanced technologies have been applied and greatly contributed to the recent progress. Optogenetic (and chemogenetic) approaches map input and output pathways of particular subpopulations of GABAergic neurons. In vivo Ca2+ imaging using GRIN lens and GCaMP can correlate the activity of GABAergic neuron subpopulations with feeding behavior. Single-cell RNA-seq approach clarifies precise transcriptional profiles of GABAergic neuron subpopulations. These approaches have shown diversity of GABAergic neurons and the subpopulation-dependent role in feeding regulation.
引用
收藏
页码：717 / 722
页数：6
相关论文
共 51 条
  • [21] Caloric restriction selectively reduces the GABAergic phenotype of mouse hypothalamic proopiomelanocortin neurons[J]. Jarvie, Brooke C.;King, Connie M.;Hughes, Alexander R.;Dicken, Matthew S.;Dennison, Christina S.;Hentges, Shane T. JOURNAL OF PHYSIOLOGY-LONDON, 2017(02)
  • [22] Expression of GABAergic and Glutamatergic Phenotypic Markers in Hypothalamic Proopiomelanocortin Neurons[J]. Jarvie, Brooke C.;Hentges, Shane T. JOURNAL OF COMPARATIVE NEUROLOGY, 2012(17)
  • [23] Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors[J]. Jennings, Joshua H.;Ung, Randall L.;Resendez, Shanna L.;Stamatakis, Alice M.;Taylor, Johnathon G.;Huang, Jonathan;Veleta, Katie;Kantak, Pranish A.;Aita, Megumi;Shilling-Scrivo, Kelson;Ramakrishnan, Charu;Deisseroth, Karl;Otte, Stephani;Stuber, Garret D. CELL, 2015(03)
  • [24] Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia[J]. Kim, Eun Ran;Wu, Zhaofei;Sun, Hao;Xu, Yuanzhong;Mangieri, Leandra R.;Xu, Yong;Tong, Qingchun. JOURNAL OF NEUROSCIENCE, 2015(29)
  • [25] Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus Ca2+ signalling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin[J]. Kohno, D;Gao, HZ;Muroya, S;Kikuyama, S;Yada, T. DIABETES, 2003(04)
  • [26] Leptin suppresses ghrelin-induced activation of neuropeptide y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway[J]. Kohno, Daisuke;Nakata, Masanori;Maekawa, Fumihiko;Fujiwara, Ken;Maejima, Yuko;Kuramochi, Motoki;Shimazaki, Takuya;Okano, Hideyuki;Onaka, Tatsushi;Yada, Toshihiko. ENDOCRINOLOGY, 2007(05)
  • [27] An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger[J]. Krashes, Michael J.;Shah, Bhavik P.;Madara, Joseph C.;Olson, David P.;Strochlic, David E.;Garfield, Alastair S.;Linh Vong;Pei, Hongjuan;Watabe-Uchida, Mitsuko;Uchida, Naoshige;Liberles, Stephen D.;Lowell, Bradford B. NATURE, 2014(7491)
  • [28] Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP[J]. Krashes, Michael J.;Shah, Bhavik P.;Koda, Shuichi;Lowell, Bradford B. CELL METABOLISM, 2013(04)
  • [29] Rapid, reversible activation of AgRP neurons drives feeding behavior in mice[J]. Krashes, Michael J.;Koda, Shuichi;Ye, ChianPing;Rogan, Sarah C.;Adarns, Andrew C.;Cusher, Daniel S.;Maratos-Flier, Eleftheria;Roth, Bryan L.;Lowell, Bradford B. JOURNAL OF CLINICAL INVESTIGATION, 2011(04)
  • [30] Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter[J]. Liu, HY;Kishi, T;Roseberry, AG;Cai, XL;Lee, CE;Montez, JM;Friedman, JM;Elmquist, JK. JOURNAL OF NEUROSCIENCE, 2003(18)
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