Carbon monoxide and its donors - Chemical and biological properties

被引：47

作者：

Adach, Weronika ^{[1
]}

Blaszczyk, Mateusz ^{[1
]}

Olas, Beata ^{[1
]}

机构：

[1] Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biochem, Pomorska 141-143, PL-90236 Lodz, Poland

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2020年 / 318卷

关键词：

Carbon monoxide; CORM; Chemical; Biological properties; THERAPEUTIC APPLICATIONS; CO; MOLECULES; CORM-2; COMPLEXES;

D O I：

10.1016/j.cbi.2020.108973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbon monoxide (CO) is an inorganic chemical compound that can bind with hemoglobin with highly toxic effects. In living organisms, it is produced endogenously during the degradation of heme by oxygenase, which occurs in three isoforms: HO-1, HO-2 and HO-3. CO can play an important role in the regulation of many physiological functions. Carbon Oxide Releasing Molecules (CORMS) are a novel group of chemical compounds capable of controlled CO release directly in tissues or organs. This release depends on concentration, pH, solvent type and temperature. The biological role and the therapeutic potential of different CORMS is not always well demonstrated. However, this mini review summarizes the various function of these compounds.

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