EXTRAPULMONARY PATHOPHYSIOLOGICAL MANIFESTATIONS CAUSED BY COVID-19 IN HUMANS

SARS-CoV-2 is the agent causing of COVID-19 and has become the world's largest public health emergency. Initially it was treated as a pneumonia because it affected the lungs of infected individuals, however, with the advance of knowledge about the disease, other pathophysiological manifestations in different organs were noticed and as the studies advance, other conditions are registered. The present study aims to describe the extrapulmonary manifestation of COVID-19, covering different locations such as the stomatognathic system, renal, gastrointestinal, cardiovascular and nervous systems. It is an integrative literature review, carried out in the MEDLINE / pubmed, LILACS and Google Scholar databases, using the descriptors: "Coronavirus Infections", "Cardiovascular System", "Oral Manifestations", "Urinary Tract", " Digestive System Abnormalities "and" Neurologic Manifestations". After applying the inclusion criteria, the search resulted in 31 articles included. Studies have shown that the infection of human cells occurs via the angiotensin-converting enzyme 2 (ACE-2), and this is a possible explanation for the fact that this virus affect several systems. After analyzing the studies, it is clear that the virus can prove complications such as arrhythmias, heart failure, oral ulcerations, proteinuria, renal dysfunction, encephalopathy, stroke, Guillan-Barre syndrome, diarrhea, nausea, vomiting, liver and pancreatic complications. It is necessary that the healthcare team is able to notice signs and symptoms beyond the respiratory tract, since they can be severe and thus guarantee better health care for patients .