Experimental evaluation of coronary collateral development

被引：38
作者：
Unger, EF [1 ]
机构：
[1] US FDA, Div Clin Trial Design & Anal, Off Therapeut Res & Review, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA
来源：
CARDIOVASCULAR RESEARCH | 2001年 / 49卷 / 03期
关键词：
blood flow; collateral circulation; coronary circulation; microcirculation; regional blood flow;
D O I：
10.1016/S0008-6363(00)00285-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
During the last decade, there has been great interest in the potential use of biologic agents and mechanical techniques to enhance myocardial collateral development. Available experimental methods to detect the effects of interventions designed to improve collateral function include assessment of vascular cell proliferation, quantification of vessel number and size, appraisal of myocardial perfusion, and evaluation of myocardial function. The purpose of this review is to discuss the various experimental approaches for the evaluation of coronary collateral development, highlighting the relative strengths and limitations of the commonly used animal models and methods of assessment. Published by Elsevier Science B.V.
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收藏
页码：497 / 506
页数：10
相关论文
共 44 条
[11]  
De Hert S, 1990, Acta Anaesthesiol Belg, V41, P327
[12]   IMMUNOHISTOCHEMICAL DETECTION OF PROLIFERATING CELLS INVIVO [J].
DEFAZIO, A ;
LEARY, JA ;
HEDLEY, DW ;
TATTERSALL, MHN .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1987, 35 (05) :571-577
[13]   ACCELERATION OF CORONARY COLLATERAL DEVELOPMENT BY HEPARIN IN CONSCIOUS DOGS [J].
FUJITA, M ;
MIKUNIYA, A ;
TAKAHASHI, M ;
GADDIS, R ;
HARTLEY, J ;
MCKOWN, D ;
FRANKLIN, D .
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1987, 51 (04) :395-402
[14]  
FUSTER V, 1990, CIRCULATION, V82, P47
[15]  
GHAZVINI S, 1995, INVEST OPHTH VIS SCI, V36, P2762
[16]   Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart [J].
Giordano, FJ ;
Ping, PP ;
McKirnan, MD ;
Nozaki, S ;
DeMaria, AN ;
Dillmann, WH ;
MathieuCostello, O ;
Hammond, HK .
NATURE MEDICINE, 1996, 2 (05) :534-539
[17]   EVALUATION OF NONRADIOACTIVE, COLORED MICROSPHERES FOR MEASUREMENT OF REGIONAL MYOCARDIAL BLOOD-FLOW IN DOGS [J].
HALE, SL ;
ALKER, KJ ;
KLONER, RA .
CIRCULATION, 1988, 78 (02) :428-434
[18]   PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IMMUNOLOCALIZATION IN PARAFFIN SECTIONS - AN INDEX OF CELL-PROLIFERATION WITH EVIDENCE OF DEREGULATED EXPRESSION IN SOME NEOPLASMS [J].
HALL, PA ;
LEVISON, DA ;
WOODS, AL ;
YU, CCW ;
KELLOCK, DB ;
WATKINS, JA ;
BARNES, DM ;
GILLETT, CE ;
CAMPLEJOHN, R ;
DOVER, R ;
WASEEM, NH ;
LANE, DP .
JOURNAL OF PATHOLOGY, 1990, 162 (04) :285-294
[19]   BASIC FIBROBLAST GROWTH-FACTOR IMPROVES MYOCARDIAL-FUNCTION IN CHRONICALLY ISCHEMIC PORCINE HEARTS [J].
HARADA, K ;
GROSSMAN, W ;
FRIEDMAN, M ;
EDELMAN, ER ;
PRASAD, PV ;
KEIGHLEY, CS ;
MANNING, WJ ;
SELLKE, FW ;
SIMONS, M .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (02) :623-630
[20]   VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts [J].
Hariawala, MD ;
Horowitz, JR ;
Esakof, D ;
Sheriff, DD ;
Walter, D ;
Keyt, B ;
Isner, JM ;
Symes, JF .
JOURNAL OF SURGICAL RESEARCH, 1996, 63 (01) :77-82
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