Defined gut microbial communities: promising tools to understand and combat disease

被引：12

作者：

Bayer, Giuliano ^{[1
]}

Ganobis, Caroline M. ^{[2
]}

Allen-Vercoe, Emma ^{[2
]}

Philpott, Dana J. ^{[1
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[2] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada

来源：

MICROBES AND INFECTION | 2021年 / 23卷 / 6-7期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

Gut microbiota; Defined microbial community; Bacteriotherapy; Gnotobiotic; In vitro models; In vivo models; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; HOST INTERACTIONS; DIETARY FIBER; MODEL; PROBIOTICS; STABILITY; BARRIER; MIXTURE; SUPPLEMENTATION;

D O I：

10.1016/j.micinf.2021.104816

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defined gut microbial communities are emerging tools that allow detailed studies of microbial ecosystems and their interactions with the host. In this article, we review strategies underlying the design of defined consortia and summarize the efforts to introduce simplified communities into in vitro and in vivo models. We conclude by highlighting the potential of defined microbial ecosystems as effective modulation strategies for health benefits. (c) 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页数：13

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