Radiation therapy and early breast cancer: current controversies

被引：36

作者：

Boyages, John ^{[1
]}

机构：

[1] Macquarie Univ, Sydney, NSW, Australia

来源：

MEDICAL JOURNAL OF AUSTRALIA | 2017年 / 207卷 / 05期

关键词：

SURGICAL ADJUVANT BREAST; MAMMARY NODE IRRADIATION; LUMPECTOMY PLUS TAMOXIFEN; 20-YEAR FOLLOW-UP; CONSERVING SURGERY; LOCOREGIONAL RECURRENCE; NEOADJUVANT CHEMOTHERAPY; RANDOMIZED-TRIAL; AMERICAN SOCIETY; POSTMASTECTOMY RADIATION;

D O I：

10.5694/mja16.01020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Radiation therapy (RT) is an important component of breast cancer treatment. RT reduces local recurrence and breast cancer mortality after breast conservation for all patients and for node-positive patients after a mastectomy. Short courses of RT over 3-4 weeks are generally as effective as longer courses. A patient subgroup where RT can be avoided after conservative surgery has not been consistently identified. A radiation boost reduces the risk of a recurrence in the breast but may be omitted for older patients with good prognosis tumours with clear margins. Axillary recurrences can take a long time to appear, with 35% occurring after 5 years. Leaving disease untreated in regional nodes is associated with reduced survival. Not all patients require radiation after neoadjuvant chemotherapy and a subsequent mastectomy. Modern RT equipment and techniques will further improve survival rates.

引用

页码：216 / 222

页数：7

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