Skeletal muscle adiponectin induction in obesity and exercise

被引:70
作者
Martinez-Huenchullan, Sergio F. [1 ,2 ]
Tam, Charmaine S. [3 ,4 ]
Ban, Linda A. [1 ]
Ehrenfeld-Slater, Pamela [5 ,6 ]
Mclennan, Susan V. [1 ,7 ,8 ]
Twigg, Stephen M. [1 ,8 ]
机构
[1] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Greg Brown Diabet & Endocrinol Lab, Sydney, NSW, Australia
[2] Univ Austral Chile, Sch Phys Therapy, Fac Med, Valdivia, Chile
[3] Univ Sydney, Northern Clin Sch, Sydney, NSW, Australia
[4] Univ Sydney, Ctr Translat Data Sci, Sydney, NSW, Australia
[5] Univ Austral Chile, Fac Med, Inst Anat Histol & Pathol, Lab Cellular Pathol, Valdivia, Chile
[6] Ctr Interdisciplinario Estudios Sistema Nervioso, Valdivia, Chile
[7] New South Wales Hlth Pathol, Newcastle, NSW, Australia
[8] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW, Australia
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2020年 / 102卷
基金
英国医学研究理事会;
关键词
AdipoQ; High-fat diet; Skeletal muscle; Exercise; IN-VIVO; PPAR-GAMMA; MYOKINE; EXPRESSION; GENE; MICE; INTERLEUKIN-6; RECEPTORS; IRISIN;
D O I
10.1016/j.metabol.2019.154008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent scientific efforts have focused on the detrimental effects that obesity has on the metabolic function of skeletal muscles and whether exercise can improve this dysfunction. In this regard, adiponectin, with important metabolic functions (e.g. insulin-sensitizer and anti-inflammatory), has been recently described as a myokine that acts in an autocrine/paracrine manner. Earlier studies reported that muscle adiponectin could be induced by pro-inflammatory mediators (e.g. lipopolysaccharide), cytokines, and high-fat diets, providing a protective mechanism of this tissue against metabolic insults. However, when metabolic insults such as high-fat diets are sustained this protective response becomes dysregulated, making the skeletal muscle susceptible to metabolic impairments. Recent studies have suggested that exercise could prevent or even reverse this process. Considering that most scientific knowledge on adiponectin clysregulation in obesity is from the study of adipose tissue, the present review summarizes and discusses the literature available to date regarding the effects of obesity on skeletal muscle adiponectin induction, along with the potential effects of different exercise prescriptions on this response in an obesity context. (C) 2019 Elsevier Inc. All rights reserved.
引用
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页数:8
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