The complete genome sequence of Bifidobacterium longum LTBL16, a potential probiotic strain from healthy centenarians with strong antioxidant activity

被引：26

作者：

Huang, Guohong ^{[1
,2
]}

Pan, Haibo ^{[1
]}

Zhu, Zhenjun ^{[1
]}

Li, Quanyang ^{[1
]}

机构：

[1] Guangxi Univ, Coll Light Ind & Food Engn, 100 Daxue Rd, Nanning 530004, Peoples R China

[2] Guangxi Vocat & Tech Coll, Coll Food & Biol Technol, Ming Yang Ind Pk, Nanning 530226, Peoples R China

来源：

GENOMICS | 2020年 / 112卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Bifidobacterium; Oxygen resistance; Scavenge free radical; Healthy centenarians; DNA-DAMAGE;

D O I：

10.1016/j.ygeno.2019.05.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

B. longum LTBL16 is a potential probiotic strain that was isolated from healthy centenarians in Bama, China. In vitro experiments show that B. longum LTBL16 has a strong antioxidant activity and the complete genome of B. longum LTBL16 was sequenced in this work. The genome consists of one 2,430,682 bp circular chromosome that is plasmid free. The circular chromosome has a GC content of 61.23% and contains 2071 coding sequences (CDSs), 4 rRNA manipulators and 55 tRNA coding genes. Genetic analysis showed that at least five protein-coding genes were associated with antioxidant activity, and the abundance of these genes may be related to free radical scavenging rates and oxygen tolerance. In addition, the safety of B. longum LTBL16 was evaluated using a virulence factor database and antibiotic resistance gene database. The results indicate that B. longum LTBL16 has the good potential for the development and utilization as a probiotic.

引用

页码：769 / 773

页数：5

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