PPARγ Agonists: Emergent Therapy in Endometriosis

被引：12
作者：
Vallee, Alexandre [1 ]
Vallee, Jean-Noel [2 ,3 ]
Le Blanche, Alain [4 ,5 ,6 ]
Lecarpentier, Yves [7 ]
机构：
[1] Foch Hosp, Dept Clin Res & Innovat DRCI, F-92150 Suresnes, France
[2] Univ Picardie Jules Verne UPJV, CHU Amiens Picardie, F-80000 Amiens, France
[3] Univ Poitiers, CNRS, UMR 7348, DACTIM Mis,Lab Math & Applicat LMA, F-86000 Poitiers, France
[4] Univ Paris Nanterre, UPL, Lab CeRSM EA 2931, F-92000 Nanterre, France
[5] Hop Rene Dubos Pontoise, F-78180 Montigny Le Bretonneux, France
[6] Univ Versailles St Quentin, Simone Veil UFR Sci Sante, F-78180 Montigny Le Bretonneux, France
[7] Grand Hop Est Francilien GHEF, Ctr Rech Clin, F-77100 Meaux, Seine & Marne, France
来源：
PHARMACEUTICALS | 2021年 / 14卷 / 06期
关键词：
endometriosis; PPAR gamma agonists; inflammation; angiogenesis; apoptosis; invasion; adhesion; ACTIVATED-RECEPTOR-GAMMA; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; DUAL-SPECIFICITY PHOSPHATASE-2; CANCER-CELL-PROLIFERATION; WNT/BETA-CATENIN PATHWAY; NECROSIS-FACTOR-ALPHA; II TYPE-1 RECEPTOR; IN-VITRO MODEL; STROMAL CELLS;
D O I：
10.3390/ph14060543
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Endometriosis is one of the major gynecological diseases of reproductive-age women. This disease is characterized by the presence of glands and stroma outside the uterine cavity. Several studies have shown the major role of inflammation, angiogenesis, adhesion and invasion, and apoptosis in endometriotic lesions. Nevertheless, the mechanisms underlying endometriotic mechanisms still remain unclear and therapies are not currently efficient. The introduction of new agents can be effective by improving the condition of patients. PPAR gamma ligands can directly modulate these pathways in endometriosis. However, data in humans remain low. Thus, the purpose of this review is to summarize the potential actions of PPAR gamma agonists in endometriosis by acting on inflammation, angiogenesis, invasion, adhesion, and apoptosis.
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页数：15
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