Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

被引:0
作者
Lee, Chia-Lin [1 ,2 ]
Hwang, Tsong-Long [3 ,4 ,5 ,6 ]
Peng, Chieh-Yu [2 ,7 ]
Chen, Chao-Jung [8 ,9 ]
Kuo, Chao-Lin [10 ]
Chang, Wen-Yi [3 ,4 ,5 ,6 ]
Wu, Yang-Chang [2 ,7 ,11 ]
机构
[1] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan
[2] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan
[3] Chang Gung Univ, Coll Med, Sch Tradit Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan
[4] Chang Gung Univ, Chinese Herbal Med Res Team, Hlth Aging Res Ctr, Taoyuan 33302, Taiwan
[5] Chang Gung Univ Sci & Technol, Dept Cosmet Sci, Taoyuan 33302, Taiwan
[6] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan 33302, Taiwan
[7] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan
[8] China Med Univ, Grad Inst Integrated Med, Taichung 40402, Taiwan
[9] China Med Univ Hosp, Dept Med Res, Prote Core Lab, Taichung 40447, Taiwan
[10] China Med Univ, Coll Pharm, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 40402, Taiwan
[11] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan
关键词
Solanum macaonense; Solanaceae; Anti-inflammation; Cytotoxicity;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 mu M; especially, 3 inhibited elastase release with an IC50 value of 4.0 mu M. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 mu M. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 mu M, respectively.
引用
收藏
页码:345 / 348
页数:4
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