Singlet oxygen quenching activity of human serum

被引:18
作者
Kon, T
Tanigawa, T
Hayamizu, K
Shen, MZ
Tsuji, T
Naito, Y
Yoshikawa, T
机构
[1] FANCL Corp, Cent Res Lab, Totsuka Ku, Kanagawa 2440806, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Inflammat & Immunol, Kyoto, Japan
[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol & Hepatol, Kyoto, Japan
关键词
singlet oxygen; human serum; smoking;
D O I
10.1179/135100004225006821
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Singlet oxygen is regarded as contributing to the pathogenesis of various diseases including light-induced skin disorders and inflammatory response. In this study, the correlation between singlet oxygen quenching activity (SOQA) of human serum and blood biochemistry or life-style was evaluated. Healthy volunteers were recruited and carried out a measurement of SOQA by using electron paramagnetic resonance (EPR) and a questionnaire survey about a smoking. It was demonstrated that major quenchers of singlet oxygen in serum are proteins, and small molecular anti-oxidants relatively play a minor role. SOQA of whole sera showed no correlation with protein concentration, but positively correlated with SOQA of small molecular fraction. In vitro studies demonstrated that the decrease of sulfhydryl groups by NO or superoxide significantly attenuated SOQA of albumin. Together, these results may imply that the underlying oxidative condition in each individual influences both small molecular antioxidant states and the sulfhydryl content of serum proteins. SOQA of sera from women with a smoking history was significantly lower compared to non-smoking women, suggesting that the smoking habit impaired the defense mechanism against singlet oxygen.
引用
收藏
页码:325 / 330
页数:6
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