Probing the sensitivity of nanowire-based biosensors using liquid-gating

被引：29
作者：
Lu, Ming-Pei [1 ]
Hsiao, Cheng-Yun [2 ]
Lai, Wen-Tsan [2 ]
Yang, Yuh-Shyong [1 ,2 ,3 ]
机构：
[1] Natl Nano Device Labs, Hsinchu 300, Taiwan
[2] Natl Chiao Tung Univ, Inst Biol Sci & Technol, Hsinchu 300, Taiwan
[3] Instrument Technol Res Ctr, Hsinchu 300, Taiwan
来源：
NANOTECHNOLOGY | 2010年 / 21卷 / 42期
关键词：
LABEL-FREE; ELECTRICAL DETECTION; NANOSENSORS; TRANSISTORS; ARRAYS;
D O I：
10.1088/0957-4484/21/42/425505
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We have used liquid-gating to investigate the sensitivity of nanowire (NW)-based biosensors for application in the field of ultrasensitive biodetection. We developed an equivalent capacitance model of the biosensor system to explore the dependence of the sensitivity on the liquid-gate voltage (V(lg)), which was influenced by capacitive competition between the NW capacitance and the thin oxide capacitance. NW biosensors with highest sensitivity were obtained when we operated the device in the subthreshold regime while applying an appropriate value of Vlg; the influence of leakage paths through the ionic solutions led, however, to significant sensitivity degradation and narrowed the operating window in the subthreshold regime.
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页数：5
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