An "off-on" optical sensor for mercury ion detection in aqueous solution and living cells

被引：19
作者：
Aydin, Ziya [1 ,2 ]
Wei, Yibin [1 ]
Guo, Maolin [1 ,2 ]
机构：
[1] Univ Massachusetts, UMass Cranberry Hlth Res Ctr, Dept Chem & Biochem, Dartmouth, MA 02747 USA
[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2014年 / 50卷
基金：
美国国家科学基金会;
关键词：
Fluorescence; Sensor; Rhodamine; Mercury ions; Live cell imaging; TURN-ON; FLUORESCENT-PROBE; NEURONAL CELLS; RHODAMINE; HG2+; CHEMOSENSORS;
D O I：
10.1016/j.inoche.2014.10.026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A rhodamine-based optical sensor Rh-3S has been developed for selective detection of Hg2+ aqueous solution as well as in living cells. UV-vis and fluorescence spectroscopic studies reveal that Rh-35 shows marked sensitivity and selectivity to Hg2+ with a chelation-induced "off-on" response in acetonitrile (ACN)/MOPS buffer (10 mM, pH 73, v/v, 1:1). The Rh-3S sensor binds Hg2+ in a 1:1 stoichiometry with an apparent binding constant 3.71 x 10(6)M(-1) (log K = 6.57) and displays a distinct change in color and fluorescence upon the alteration of free Fief levels in solution with a reversible response and little interference with other biological relevant metal ions. Live cell confocal imaging studies demonstrate that the sensor is also capable of imaging the presence of He ions as well as its dynamic changes in live cells. Published by Elsevier B.V.
引用
收藏
页码：84 / 87
页数：4
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