Tissue macrophages: heterogeneity and functions

被引：437

作者：

Gordon, Siamon ^{[1
,2
]}

Pluddemann, Annette ^{[3
]}

机构：

[1] Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Taoyuan 33302, Taiwan

[2] Univ Oxford, Sir William Dunn Sch Pathol, South Parks Rd, Oxford OX1 3RE, England

[3] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Woodstock Rd, Oxford OX2 6GG, England

来源：

BMC BIOLOGY | 2017年 / 15卷

关键词：

MONONUCLEAR PHAGOCYTE SYSTEM; IMMUNOHISTOCHEMICAL LOCALIZATION; MONOCLONAL-ANTIBODY; DENDRITIC CELLS; RESIDENT MACROPHAGES; CARDIAC MACROPHAGES; ENDOTHELIAL-CELLS; LIVER MACROPHAGES; MANNOSE RECEPTOR; ANTIGEN F4/80;

D O I：

10.1186/s12915-017-0392-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.

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页数：18

相关论文

共 135 条

[11] Niche heterogeneity in the bone marrow [J].

Birbrair, Alexander ;

Frenette, Paul S. .

HEMATOPOIETIC STEM CELLS IX, 2016, 1370 :82-96

[12] Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection [J].

Bleriot, Camille ;

Dupuis, Theo ;

Jouvion, Gregory ;

Eberl, Gerard ;

Disson, Olivier ;

Lecuit, Marc .

IMMUNITY, 2015, 42 (01) :145-158

[13] Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies [J].

Bowman, Robert L. ;

Klemm, Florian ;

Akkari, Leila ;

Pyonteck, Stephanie M. ;

Sevenich, Lisa ;

Quail, Daniela F. ;

Dhara, Surajit ;

Simpson, Kenishana ;

Gardner, Eric E. ;

Iacobuzio-Donahue, Christine A. ;

Brennan, Cameron W. ;

Tabar, Viviane ;

Gutin, Philip H. ;

Joyce, Johanna A. .

CELL REPORTS, 2016, 17 (09) :2445-2459

[14] Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System [J].

Bruttger, Julia ;

Karram, Khalad ;

Woertge, Simone ;

Regen, Tommy ;

Marini, Federico ;

Hoppmann, Nicola ;

Klein, Matthias ;

Blank, Thomas ;

Yona, Simon ;

Wolf, Yochai ;

Mack, Matthias ;

Pinteaux, Emmanuel ;

Mueller, Werner ;

Zipp, Frauke ;

Binder, Harald ;

Bopp, Tobias ;

Prinz, Marco ;

Jung, Steffen ;

Waisman, Ari .

IMMUNITY, 2015, 43 (01) :92-106

[15] The pancreas anatomy conditions the origin and properties of resident macrophages [J].

Calderon, Boris ;

Carrero, Javier A. ;

Ferris, Stephen T. ;

Sojka, Dorothy K. ;

Moore, Lindsay ;

Epelman, Slava ;

Murphy, Kenneth M. ;

Yokoyama, Wayne M. ;

Randolph, Gwendalyn J. ;

Unanue, Emil R. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (10) :1497-1512

[16] Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice [J].

Chinnery, Holly R. ;

Ruitenberg, Marc J. ;

McMenamin, Paul G. .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2010, 69 (09) :896-909

[17] Human dendritic cell deficiency: the missing ID? [J].

Collin, Matthew ;

Bigley, Venetia ;

Haniffa, Muzlifah ;

Hambleton, Sophie .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (09) :575-583

[18]

CROCKER PR, 1990, BLOOD, V76, P1131

[19] ISOLATION AND CHARACTERIZATION OF RESIDENT STROMAL MACROPHAGES AND HEMATOPOIETIC-CELL CLUSTERS FROM MOUSE BONE-MARROW [J].

CROCKER, PR ;

GORDON, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (03) :993-1014

[20] Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection [J].

Cronan, Mark R. ;

Beerman, Rebecca W. ;

Rosenberg, Allison F. ;

Saelens, Joseph W. ;

Johnson, Matthew G. ;

Oehlers, Stefan H. ;

Sisk, Dana M. ;

Smith, Kristen L. Jurcic ;

Medvitz, Neil A. ;

Miller, Sara E. ;

Trinh, Le A. ;

Fraser, Scott E. ;

Madden, John F. ;

Turner, Joanne ;

Stout, Jason E. ;

Lee, Sunhee ;

Tobin, David M. .

IMMUNITY, 2016, 45 (04) :861-876

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