Tissue macrophages: heterogeneity and functions

被引：437
作者：
Gordon, Siamon [1 ,2 ]
Pluddemann, Annette [3 ]
机构：
[1] Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Taoyuan 33302, Taiwan
[2] Univ Oxford, Sir William Dunn Sch Pathol, South Parks Rd, Oxford OX1 3RE, England
[3] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Woodstock Rd, Oxford OX2 6GG, England
来源：
BMC BIOLOGY | 2017年 / 15卷
关键词：
MONONUCLEAR PHAGOCYTE SYSTEM; IMMUNOHISTOCHEMICAL LOCALIZATION; MONOCLONAL-ANTIBODY; DENDRITIC CELLS; RESIDENT MACROPHAGES; CARDIAC MACROPHAGES; ENDOTHELIAL-CELLS; LIVER MACROPHAGES; MANNOSE RECEPTOR; ANTIGEN F4/80;
D O I：
10.1186/s12915-017-0392-4
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.
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页数：18
相关论文
共 135 条
[1]   Phagocytosis imprints heterogeneity in tissue-resident macrophages [J].
A-Gonzalez, Noelia ;
Quintana, Juan A. ;
Garcia-Silva, Susana ;
Mazariegos, Marina ;
Gonzalez de la Aleja, Arturo ;
Nicolas-Avila, Jose A. ;
Walter, Wencke ;
Adrover, Jose M. ;
Crainiciuc, Georgiana ;
Kuchroo, Vijay K. ;
Rothlin, Carla V. ;
Peinado, Hector ;
Castrillo, Antonio ;
Ricote, Mercedes ;
Hidalgo, Andres .
JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (05) :1281-1296
[2]   The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis [J].
Amit, Ido ;
Winter, Deborah R. ;
Jung, Steffen .
NATURE IMMUNOLOGY, 2016, 17 (01) :18-25
[3]   Adaptive Characteristics of Innate Immune Responses in Macrophages [J].
Arts, Rob J. W. ;
Netea, Mihai G. .
MICROBIOLOGY SPECTRUM, 2016, 4 (04)
[4]   A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules [J].
Aspelund, Aleksanteri ;
Antila, Salli ;
Proulx, Steven T. ;
Karlsen, Tine Veronica ;
Karaman, Sinem ;
Detmar, Michael ;
Wiig, Helge ;
Alitalo, Kari .
JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (07) :991-999
[5]   Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior [J].
Auffray, Cedric ;
Fogg, Darin ;
Garfa, Meriem ;
Elain, Gaelle ;
Join-Lambert, Olivier ;
Kayal, Samer ;
Sarnacki, Sabine ;
Cumano, Ana ;
Lauvau, Gregoire ;
Geissmann, Frederic .
SCIENCE, 2007, 317 (5838) :666-670
[6]   F4-80, A MONOCLONAL-ANTIBODY DIRECTED SPECIFICALLY AGAINST THE MOUSE MACROPHAGE [J].
AUSTYN, JM ;
GORDON, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1981, 11 (10) :805-815
[7]   Dendritic Cells in the Immune System-History, Lineages, Tissues, Tolerance, and Immunity [J].
Austyn, Jonathan M. .
MICROBIOLOGY SPECTRUM, 2016, 4 (06)
[8]   Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice [J].
Bain, Calum C. ;
Bravo-Blas, Alberto ;
Scott, Charlotte L. ;
Perdiguero, Elisa Gomez ;
Geissmann, Frederic ;
Henri, Sandrine ;
Malissen, Bernard ;
Osborne, Lisa C. ;
Artis, David ;
Mowat, Allan Mci .
NATURE IMMUNOLOGY, 2014, 15 (10) :929-U236
[9]   Evolution of Myeloid Cells [J].
Barreda, Daniel R. ;
Neely, Harold R. ;
Flajnik, Martin F. .
MICROBIOLOGY SPECTRUM, 2016, 4 (03)
[10]  
BESSIS M, 1958, Rev Hematol, V13, P8
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