Early inflammatory and myogenic responses to resistance exercise in the elderly

被引：25
|
作者：
Mathers, Jessica L. [2 ]
Farnfield, Michelle M. [2 ]
Garnham, Andrew P. [2 ]
Caldow, Marissa K. [2 ]
Cameron-Smith, David [3 ]
Peake, Jonathan M. [1 ]
机构：
[1] Univ Queensland, Sch Human Movement Studies, St Lucia, Qld 4072, Australia
[2] Deakin Univ, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia
[3] Univ Auckland, Liggins Inst, Auckland 1, New Zealand
来源：
MUSCLE & NERVE | 2012年 / 46卷 / 03期
关键词：
aging; inflammation; muscle damage; myokine; regeneration; INFLUENCE POSTEXERCISE INDEXES; HUMAN SKELETAL-MUSCLE; MONOCYTE CHEMOTACTIC PROTEIN-3; POINT-COUNTERPOINT ESTROGEN; MYOSTATIN GENE-EXPRESSION; SEX DO/DO; ECCENTRIC EXERCISE; OLDER-ADULTS; MYOFIBER HYPERTROPHY; POSTMENOPAUSAL WOMEN;
D O I：
10.1002/mus.23317
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 +/- 1.0 years) and 15 elderly women (67.2 +/- 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1 beta, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1 beta, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury. Muscle Nerve 46: 407412, 2012
引用
收藏
页码：407 / 412
页数：6
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