Harnessing human plasmacytoid dendritic cells as professional APCs

被引：51
作者：
Tel, Jurjen [1 ,2 ]
van der Leun, Anne M. [1 ,2 ]
Figdor, Carl G. [1 ,2 ]
Torensma, Ruurd [1 ,2 ]
de Vries, I. Jolanda M. [1 ,2 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands
[2] Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
来源：
CANCER IMMUNOLOGY IMMUNOTHERAPY | 2012年 / 61卷 / 08期
关键词：
PIVAC; 11; Plasmacytoid dendritic cells; Antigen-uptake receptors; Antigen presentation; Targeting; CD8(+) T-CELLS; ANTIGEN PRESENTATION; CROSS-PRESENTATION; INFLUENZA-VIRUS; IN-VIVO; FUNCTIONAL SPECIALIZATION; MELANOMA PATIENTS; LECTIN RECEPTORS; SIGLEC-H; IMMUNE;
D O I：
10.1007/s00262-012-1210-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted, their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture, process and (cross-) present antigen.
引用
收藏
页码：1279 / 1288
页数：10
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