The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G2 checkpoint inhibitor

被引：22

作者：

Reddy, Gandolla Chinna ^{[1
]}

Balasubramanyam, Penagaluri ^{[1
]}

Salvanna, N. ^{[1
]}

Reddy, Thummala Sreenivasulu ^{[2
]}

Das, Biswanath ^{[1
]}

机构：

[1] Indian Inst Chem Technol CSIR, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Sri Krishnadevaraya Univ, Dept Chem, Anantapur 515003, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 07期

关键词：

(Z)-cryptomoscatone D2; Stereoselective synthesis; Maruoka allylation; Ring closing metathesis; Lindlar's catalyst;

D O I：

10.1016/j.bmcl.2012.02.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first stereoselective synthesis of (Z)-cryptomoscatone D2, a naturally occurring G 2 checkpoint inhibitor, was accomplished using propane-1,3-diol as the starting material. The Maruoka asymmetric allylation, ring closing metathesis and the hydrogenation of the triple bond employing Lindlar's catalyst were involved as the key steps. © 2011 Elsevier Ltd. All rights reserved.

引用

页码：2415 / 2417

页数：3

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