Cooperativity, sensitivity, and noise in biochemical signaling

被引：68

作者：

Bialek, William ^{[1
,2
]}

Setayeshgar, Sima ^{[3
]}

机构：

[1] Princeton Univ, Joseph Henry Labs Phys, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[2] Princeton Univ, Princeton Ctr Theoret Phys, Princeton, NJ 08544 USA

[3] Indiana Univ, Dept Phys, Bloomington, IN 47405 USA

来源：

PHYSICAL REVIEW LETTERS | 2008年 / 100卷 / 25期

关键词：

D O I：

10.1103/PhysRevLett.100.258101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Cooperative interactions in the binding of multiple signaling molecules is a common mechanism for enhancing the sensitivity of biological signaling systems. It is widely assumed this increase in sensitivity of the mean response implies the ability to detect smaller signals. Extending the classic work of Berg and Purcell [Biophys. J. 20, 193 (1977)] on the physical limits of chemoreception, we show that the random arrival of diffusing signaling molecules at receptor sites constitutes a noise source that is not reduced by cooperativity. Cooperativity makes reaching this limit easier, but cannot reduce the limit itself.

引用

页数：4